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Vaccine Safety Forum Summaries of Two Workshops (1997) / Chapter Skim
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ADDITIONAL AREAS FOR RESEARCH
Pages 18-20

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From page 18...
... Some studies also suggest that influenza virus or pneumococcal vaccines given to HIV-infected individuals with advanced disease can increase the amount of HIV in their bodies (Janoff et al., 1995; O'Brien et al., 1995; Tasker et al., 1995~. In addition, one study that used LLDBs reported that neurologically impaired children were at a much greater risk of having seizures following childhood vaccinations than a healthy control group (Davis, unpublished data)
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From page 19...
... Currently, because of the need for close monitoring, accessibility to health care, and data analysis, as well as exclusion criteria for the study of experimental vaccines, clinical trials of vaccines are usually done with a homogeneous population of healthy individuals least likely to experience adverse reactions to the vaccines. Because subpopulations can differ both in their risk of experiencing adverse reactions to a vaccine and in their risk of the disease that the vaccine is designed to prevent, studies to evaluate risks in specific subpopulations could provide needed information.
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From page 20...
... According to workshop participants, these findings reinforce the need for longterm studies to determine late-onset adverse effects of vaccines. They also suggest that newly devised laboratory tools for virus detection such as the polymerase chain reaction should perhaps be applied even to those vaccines that have historically been accepted as safe to detect adventitious viruses that might cause long-term adverse effects.
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  • specific subpopulations
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