Vaccine Safety Forum Summaries of Two Workshops (1997) / Chapter Skim
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RESEARCH OPPORTUNITIES
RESEARCH OPPORTUNITIES
Pages 44-50
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From page 44... ...
These families could be identified by using the LLDB, which could also be used to identify twins useful in the study of genetic differences associated with the risk of adverse events following vaccination. To prioritize which genetic populations should be studied, the speaker suggested creating ranked categories of conditions on the basis of the most frequent claims under the Vaccine Injury Compensation Program, and among those, the conditions most likely to have a genetic susceptibility component worthy of study.
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From page 45... ...
Consumer advocates also question whether there are differences in longterm immunologic function and health status between children who receive vaccinations and those who do net. Several vaccine manufacturer representatives and biomedical researchers noted that it would be a challenge to conduct studies aimed at assessing the long-term immunologic effects of vaccination versus nonvaccination.
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From page 46... ...
She and Kinsbourne, a pediatric neurologist, noted that a vaccine that might, in rare cases, cause severe brain damage might more frequently cause milder forms of brain damage that could manifest itself as a learning disability or attention deficit disorder. This hypothesis is based on evidence that some causes of brain damage, such as low oxygen conditions during birth, not only cause severe mental retardation or cerebral palsy but are also associated with an increased risk of the hyperactive impulsive behavior that is seen in children with attention deficit disorder (Nichols and Chen, 1981; Astbury et al., 19871.
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From page 47... ...
Potential outcome variables of particular interest would be attention deficit-hyperactivity disorder, selective learning disabilities, and clumsiness with motor soft signs. Fisher's fourth research priority was that researchers conduct studies to investigate the possible link between vaccines and autism.
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From page 48... ...
This could be relatively easily assessed with epidemiologic studies with data collected in other established studies of health care workers. A CDC representative pointed out, however, that MS initially occurs most often in young women.
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From page 49... ...
Several speakers suggested research avenues that might prove fruitful in this regard, including studies that assess the risk of adverse events after vaccination in specific genetic populations; on a molecular biology level, the impact over time of multiple vaccination; whether there is a link between learning disabilities and vaccination; whether autistic children have different immune responses than nonautistic children; whether health care workers vaccinated with the hepatitis B virus vaccine (HBV) experience more autoimmune disorders; and whether the antigens in vaccines are likely to cause demyelinating disorders.
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