Research Priorities for Airborne Particulate Matter I. Immediate Priorities and a Long-Range Research Portfolio (1998) / Chapter Skim
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Appendix B
Appendix B
Pages 139-195
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From page 139... ...
Appendix B PARTICULATE-MATTER RESEARCH INVENTORY (IN PROGRESS) Prepared by Maria Costantini, Health Effects Institute John Vandenberg, U.S.
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Contractor: TBA Experimental/mechanisms "Impact of inhaled particles on canine electrocardiography Examination of the role of soluble metals in the toxicity of particulate matter". Contractor: Joe Maucierly, Lovelace Respiratory Research Institute.
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Contractor: Petros Koutrakis, Harvard School of Public Health. "Measurement of personal exposure to multiple criteria and hazardous air pollutants".
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(3) Experimental/mechanisms "Effects of Exposure to Fine and Ultrafine Ammonium Nitrate and Carbon Particles on: Cytotoxicity, Cell Proliferation, Particle Clearance, Histopathology, OxicIative Stress, Macrophage Function, Production of NO, Carciio-Pulmonary Response, in Young, Adult, and Old Rats" U CAL Davis and U CAL Irvine Collaborative PM Research Exposure assessment and relationships Determine the level of particles and vapor-phase organics inside cars.
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Determine the inhalability factor for particles as a function of diameter, and evaluate endotracheal intubation of rats as a means of bypassing the nose. COORDINATING RESEARCH COUNCIL Aerosol methods and monitoring "Contribution of Vehicle Emissions to Ambient Carbonaceous Particulate Matter" "Carbon Isotopic Analyses for the Norther Front Range Air Quality Study's Summer ant!
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(3) DEPARTMENT OF ENERGY Aerosol methods and monitoring Research on freshly nucleated ultrafine particles and the development of instrumentation to measure clown to 3nm-1 Onm diameter.
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" (Planned with CRC) Principal investigators: Glen Cass anti Suzanne Herring Emission characterization and source apportionment "Size ciistribution of in-use heavy-duty vehicle particulate emissions" Contract under negotiation ELECTRIC POWER RESEARCH INSTITUTE Epidemiology/acute effects Investigation of artifact - analyses of data sets to rule out the existence of an artifact in statistical analyses of time series data; review of econometric issues in data analysis.
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. Contractor: Henry Gong, Rancho Los Amigos Investigation of a heavily-exposed occupational group: personal exposures measurements and pre- ant!
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grid moclels, characterize total aerosol, define secondary organic formation Contractors:TBA Risk assessment and management/cost benefit Integrated risk management framework inclucling regional source
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ENVIRONMENTAL PROTECTION AGENCY NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT Epidemiology/acute effects Relative effects of PM2 s versus PI 0-2 5' on respiratory health indicators. Principal investigator: Douglas Dockery, Harvard School of Public Health Analysis of daily mortality in Dublin, Irelanci, in relation to particulate air pollution control.
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Relationship of personal exposure of thigh risk sub-populations to ambient concentrations of fine particles. Use of innovative monitoring techniques to estimate source strengths ant!
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ENVIRONMENTAL PROTECTION AGENCY NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY Epidemiology/acute effects Cardiopulmonary responses in elclerly persons exposed to ambient particulate air pollution. Principal investigator: John Creason Air pollution anti morbidity and mortality among California Kaiser Permanente members.
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Principal investigator: Matthew Campen and Penn Watkinson In vivo toxicity of emission and ambient air particles in animal models of cardiopulmonary disease. Principal investigator: Sarah Gardner and Urmila Kodavanti Effect of particles on innate immune responses to infection: Antimicrobial peptide gene expression and cytokine production by lung cells exposed to endotoxin ant!
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Principal investigators: John Lay and Ancirew Ghio Role of biogenic material and transition metals in particle-induced activation of human alveolar macrophages in vitro. Principal investigator: Susanne Becker Transition metal components of fine particulate air pollutants: Evaluation of airway epithelial cell response.
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Principal investigator: Chong Kim Particle deposition characterization in bifurcating airway moclels. Principal investigator: Chong Kim Effect of age on lung deposition dose of inhaled fine particles: Comparison between children, young ant!
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Sources of Fine Particulate Matter to Increased Daily Mortality" (RS2-6245)
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($383,000 - total) "Ultrafine Particle in Urban Air and Respiratory Health Among Children with RespiratoIy Symptoms".(FY 96)
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Wexier, University of Delaware ($374,833 - total) "Real-Time Monitoring of Incliviclual Atmospheric Aerosol Particles: Establishing Correlations between Particle Size and Chemical Speciation" (RS2-6240)
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"Measurement and Source Apportionment of Human Exposures to Toxic Air Pollutants in the Minneapolis-St. Paul Metropolitan Area".(FY 96)
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"Speciation of Volatile anti Reacting Compouncis in Particulate Matter" (RS2-3980)
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"Development of Population-Basec! Particle Exposure Models for Human Health Risk Assessment".(FY 96)
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"Applications of Receptor Mocieling to Time Series Data for Aerosol Chemical Components" (RS2-1288)
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antunen, National Public Health Institute, Finland ULTRA I "Exposure anti risk assessment for fine and ultrafine particles in ambient air" (3 centers)
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"A case-crossover study of fine particulate air pollution and suclden cardiac arrest" Principal investigator: Harvey Checkoway, University of Washington (RFPA 96-2) "Association of PM components with daily mortality and morbiciity in urban populations" Principal investigator: Mort Lippmann, New York University Meclical Center (RFPA 94-3)
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Experimental/health effects "Inflammatory mechanisms with exposure to air pollution particles" Principal investigator: Stephen Holgate, University of Southampton (RFA 96-l ~ Experimental/mechanisms "Mechanisms of morbiclity anti mortality from exposure to ambient air particles" Principal investigator: John Gocileski, Harvarci School of Public Health (RFA 94-2) "Adverse health effects of ambient PM~o in compromised animal models" Principal investigator: Terry Gordon, New York University Medical Center (RFA 94-2)
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LOVELACE RESPIRATORY RESEARCH INSTITUTE Experimental/health effects Study of the effects of combined exposures to cigarette smoke and other noxious agents on the induction of adverse health effects Experimental/mechanisms Standardization of an in vitro screening test for the toxicity of particles using cultured cells, co-cultureci cells, and lung slices Study of the effect of particle size on toxicity in vivo Study of electrocarciiographic changes in clogs exposeci to noxious aerosols
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Study to determine the changes in protein expression that occur in response to DNA damage from air pollutants, including particles, in vitro Review utility of animal models for research on mechanisms, susceptibility, and risk. Dosimetry Study the kinetics of inhaled ultrafine particles administered by various routes in rats and monkeys.
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"In vivo MR microscopy of environmental lung disease" Johnson Alian, Duke University Meciical Center "Aeros! probes of lung injury in a chronic ciisease model" Rosenthal Frank, Purdue University DosimetIy "Age and hotly size factors in inhaleci particle deposition" Phalen Robert, University of California at Irvine "Chaotic mixing of aerosol in rhytmically expanding lung" Tsuda Akira, Harvard School of Public Health NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES Epidemiology/Long-term effects National Cooperative Inner-City Asthma Study (]
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"National asthma inner city study-Tucson field center" 1-U01-Al-39785-02, Morgan Wayne, University of Arizona ($259,188 FY 96) "National cooperative inner city asthma stucI/' i-U01-Al-39901-02, Kattan Meyer, Mount Sinai School of Medicine ($321,909 - FY 96)
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"Effects of Environmental Pollutants on Human Lung Function" 5-P30-ES-02147-23 (S-0064) , Utell Mark, University of Rochester ($785,069 - FY 96)
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"Inhaled Pollutants - Mechanisms of Injury and Adaptation" 5-K04-ES-00256-05, Gordon Terry, New York University Medical Center ($69,174 - FY 96) "Mechanisms of Particle Incluced Lung Injury" 5-R01-ES-04872-09, Oberciorster Gunther, University of Rochester ($347,565 - FY 96)
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From page 189... ...
Appendix B.: Particulate-Matter Research Inventory, March IS, 1998 189 Z01-ES-25030-10, BonnerJC, Intramural, NIEHS Aerosol methods and monitoring "Mutagens in Ambient Airborne Organic Aerosols - Identity and Sources" 3-P01-ES-071 68-03S1 Technology Sarofim Adel, Massachusetts Institute of NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH EpidemiologylLong-term effects Mortality Follow-up of Diesel Exposeci Miners Cohort anti Case Control Stucly of Lung Cancer and Diesel Exhaust Experimental/HealtI~ Effects Cough Souncis and AerosIs as a Predictors of Respiratory Disease Occupational Asthma: High anti tow Molecular Weight Asthmagens VAG909 Pulmonary Responses to Occupational Dusts VAG913 Identification of Sub-populations Susceptible to Particle Exposure Experimental/Mechanisms Icientification of Sub-populations Susceptible to Particle Exposure VAGN31 Biomarkers of Occupational Disease Risk: Role in Human · Carclnogenesls Investigation of Occupational Diseases Caused by Metals Metals: Asthma and Hard Metal Disease
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VRE01 5 Development of a Portable XRF Unit for Air Sample Screening VAG830 Evaluation of tIF Technology for Bioaeroso} Screening Development of a Portable XRF Unit for Air Sample Screening Improved Application anti Monitoring of Dust Control Parameters Monitoring Cristalline Silica Dust ....O Atmospheric chemistry and physics, meteorology, and modeling Surface Chemistry Characterization of Respirable Particles
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Epidemiology/Ion~term effects Study in panels of children and asthmatics. Experimental/mechanisms Studies on the causality of PM health effects using inhaled CAP, fine and ultrafine particles, instilled PMi0/PM2.5 in animals with asthma, heart failure, pulmonary hypertension.
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UNITED KINGDOM DEPARTMENT OF HEALTH Epidemiology/acute effects "Effects of Air Pollution on Daily Mortality, Admissions, and General Practitioner Consultations in Loncion" Principal Investigator: Ross Anderson, St. George's Hospital Medical School "The Relationship Between Urban Pollution and Cardiorespiratory Health" Principal Investigator: Raymond Agius, University of Edinburgh "Study of the Aetiological Effect of Vehicle Traffic Pollution in the Prevalence and Natural History of Asthma in Nottingham School children" Principal Investigator: John Britton, Nottingham City Hospital "Effect of Fine Particulate Air Pollution and Acici Aerosols on Respiratory Function and Symptoms in Schooichilclren"
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Luczynska, McAughey, et al Epidemiology/long-term effects "Chronic Respiratory Health Effects of Cumulative Air Pollution Exposure: A National Birth Cohort Study" Principal Investigator: Davici Strachan, St. George's Hospital Medical School.
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Epidemiology/Sl~ort-term "Highway traffic and respiratory health" Epidemiology/Long-term "Long-term exposure to air pollution and mortality' "Development of asthma and other chronic respiratory conditions in young children" VE RBAN D ES DE R AUTOMOBILINDUSTRIE (D) Experimental/mechanisms "Comparative Pulmonary Response of Humans and Animals to Dust Exposures" Principal investigator: Fletcher Hahn / ITR} / Albuquerque Emission characterization and source apportionment "Queller tier Partikelimmission in cler AtemIuft cles Menschen (Sources of Particles)
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Appendix B.: Particulate-Matter Research inventory, March 1S, 1998 195 Principal Investigators: R Niener, University of Munich, U
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