Biographical Memoirs Volume 74 (1998) / Chapter Skim
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James Lynn Hoard
James Lynn Hoard
Pages 160-177
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international recognition for seminal en c! classic work on the stereochemical principles unclerlying high-coorclination discrete complexes, for founcling the basis for the icosaheciral crystal chemistry of elementary boron ant!
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with a remarkable memory that impartially cleliverec! long discourses on any subject that interested him phytography, meteorology, geography, Indian nations, musical scores, or the finest cletails of chemical structure.
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Phi Beta Kappa, the first chemical engineering student at the institution to be so honored. He continucc!
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Laurence. In the early years, although uncler constant pressure from Lynn's participation in the Manhattan Project en c!
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These analyses provided the first examples of discrete complexes in configurations that approximated closely to the geometries of the C2v monocapped trigonal prism, the Dad square antiprism, and most notably the DO dodecahedron having triangular faces, eight vertices, and eighteen edges. This dodecahedron emerged as the coordination polyhedron of the octacyanomolybdate (IV)
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the importance of this program in writing, Hoard's parallel interest in the structural properties of multidentate ligands has resulted in an extensive series of papers on coordination compounds of EDTA. These papers remain the outstanding source of carefully measured and critically evaluated structural data for EDTA complexes.
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Its importance is not restricted to the crystalline solid state, but many of the results are so basic and of such far reaching significance as to affect profoundly the whole fabric of inorganic chemistry, including inorganic solution chemistry .
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It was in this context that he cleciclec! to undertake the structure determination of a crystal with fifty very light boron atoms per unit cell with unknown stereochemistry.
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The principal obstacle to progress in this fielc! was the great clifficulty in producing single crystals suitable for X-ray diffraction analyses, especially for materials of biological importance.
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Hoard, relying heavily on his deep understanding of the stereochemical principles governing metal complexes, firmly postulated that "the porphine moiety, as compared with an aromatic hydrocarbon of the benzene series, is quite susceptible to significant folding, ruffling, or doming when subjected to moderate stressing." He further asserted that "a substantial displacement (2.40A) of the iron atom from the plane of the four nitrogens to which it is bonded is a
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From page 171... ...
The challenge to explain this remarkable phenomenon in stereochemical terms motivated Perutz and Kendrew to begin their now legendary crystallographic studies. Hoard's seminal contribution to our understanding the triggering stereochemical event; i.e., the displacements of the heme iron from the plane of the porphyrin, illustrates an important principle in the field of structural studies; namely, that achieving high resolution and visualizing the stereochemical details is not just an exercise in crystallographic virtuosity but rather, the "details" of a high resolution image often provide a paradigm-shifting observation that is the key to a chemical mechanism.
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Nevertheless, even as he strides into Baker Lab freshly tanned from the Foro Romano, Lynn Hoard remains one of Ithaca's most familiar and important institutions.
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Service in the Advancement of Inorganic Chemistry. Perhaps the most significant recognition he receiver!
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Oak Ridge: U.S. Atomic Energy Commission, Technical Information Service Extension.
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The crystal structure and molecular stereochemistry of methoxyiron (III) mesoporphyrin-IX dimethyl ester.
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Stereochemical trigger for initiating cooperative interaction of the subunits during the oxygenation of cobaltohemoglobin.
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