Skip to main content

Health Effects of Exposure to Low Levels of Ionizing Radiations Time for Reassessment? (1998) / Chapter Skim
Currently Skimming:

Executive Summary
Pages 1-4

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 1...
... The intent of the workshop was to address the implications of new understanding of the biologic basis of radiation injury and carcinogenesis for risk assessment. The following is a synopsis ofthe conclusions ofthe BEIR VIT phase-1 study: Information that has become available since the 1990 publication of Health Effects of Exposure to Low Levels of ionizing Radiations (BEIR V)
Read the entire page →
From page 2...
... The committee recommends that the individuals responsible for the proposed phase-2 studly · Include a comprehensive review of all relevant epidemiologic data related to lowLET (low linear energy transfer)
Read the entire page →
From page 3...
... Specifically, the responsible committee should develop models appropriate for use in future development of probability-ofcausation tables and should consider the fitting of purely empirical models to original data from studies or combined studies, the fitting of purely empirical models with metaanalytic techniques, and the fitting of semiempirical biology-based models to epidemiologic data. With respect to modeling, the committee recommends that the individuals responsible for the proposed phase-2 study · Provide examples of specific risk calculations based on the risk models and explain the appropriate use of the models.
Read the entire page →
From page 4...
... To accomplish the charge suggested here, the membership of the committee responsible for the proposed BEIR VIT phase-2 study will require expertise in epidemiology, biostatistics, radiation physics and dosimetry, molecular biology, risk assessment and communication, cancer modeling, animal and cellular radiation biology, somatic cell genetics, cell-cycle regulation and apoptosis, and the causation and repair of DNA damage induced by ionizing radiation. The committee recommends that the experts chosen have adequate resources and access to data for the computing, statistical analyses, and modeling required to complete the study.
Read the entire page →

Key Terms

  • health risks
  • epidemiologic data
  • risk models
  • low doses
  • evidence regarding

  • adaptive responses
  • empirical models
  • proposed beir
  • purely empirical
  • genetic effects

  • target cells
  • current rapid
  • adequate resources
  • developing conservative
  • including host

  • relevant epidemiologic
  • models appropriate
  • damage induced
  • rapid developments
  • radiation physics

  • researchers responsible
  • including benign
  • risk analyses
  • chromosomal instability
  • appropriate risk

  • charge suggested
  • regarding genetic
  • major cancer
  • experts chosen
  • estimate population


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.