Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents Volume 1 (1982) / Chapter Skim
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Introduction
Introduction
Pages 1-4
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The i ssue of the use of human volunteers was considered by the Armed Forces Medical Policy Council during the early 1950' s. The Council concluded that essential data could not be obtained unless human volunteers were used, and the use of humans in medical research was author)
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However, minutes of hearings conducted by the U.S. Senate Subcommittee on Health ant Subcommittee on Administrative Practice ant Procedure, September 10-12, 1975, atatet that the consent information wee inadequate by current standards.
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As the program developed, it became customary to test agents at dose Increments of 40 percent, once the approximate effects of the lower doses were known. Placebos were used in some studies, but the cost with respect to subject confinement time, staff workload, and delay in achieving estimates of potency made this impractical except in special cases (e.g., evaluation of antagonists)
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