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Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents Volume 1 (1982) / Chapter Skim
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Appendix H: Evaluation of Data from Short-Term Testing of Anticholinergic Chemicals-- by Virginia C. Dunkel, Ph.D.
Pages 113-116

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From page 113...
... , Saccharomyces cerevisiae was used as the target cell, and the effects of the chemical were tested in a direct in vitro assay without metabolic activation and in a has unmediated modification. In the direct reverse mutation assay, there were increases by a factor of 2-6 in the number of dish revertants and by a factor of 2-7 in the number of trp+ revertants over the spontaneous frequencies.
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From page 114...
... Such an effect is indicative only of the toxic effects of the test compound, Overall, at moat a marginal response might be indicated by the results of the point-mutation aaasys with Saccharoeyces cereviaiae and the possible presence of cytogenic effecta -- breaks in Chinese hamster bone marrow cells. The Significance of these effects, however, is open to question, ant further studies are required to confirm or negate the original obaervationa.
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From page 115...
... The aberrations were gaps ant breaks, but there was no evidence of exchange figures, such as translocations. As Indicated previously, the presence of gaps is not a significant Because of clastogenic potential, ant the presence of breaks in a single cell line toes not establish the mutagenic potential of a chemical.
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From page 116...
... Sra2e, R.J. 1975: Cytogenic analysis of 3-chinuclidylbenzilate, 3-chinuclidinol ant benaceyzine in bone marrow of Chinese hamater.
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Key Terms

  • genotoxic potential
  • bone marrow
  • human peripheral
  • marrow cells
  • metabolic activation

  • mammalian cells
  • genetic toxicology
  • dna damage
  • induce dna
  • toxic effects

  • chinese hamsters
  • target cell
  • potential genotoxicity
  • substantial amount
  • dna aynthesia

  • considered sufficient
  • hamster bone
  • chinese hamater
  • reverse mutation
  • les capacity

  • anticholinergic compounds
  • single cell
  • cytogenetic analyses
  • saccharoeyces cereviaiae
  • utation aaasy

  • test compound
  • unscheduled dna
  • critical macromolecules
  • eukaryotic cells
  • metabolic capabilities


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