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Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents Volume 1 (1982) / Chapter Skim
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Appendix J: Anticholinergic Drugs and the EEG-- by Max Fink, Ph.D.
Pages 263-270

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From page 263...
... The data i no lute pro tocola of military experiments teclaasifiet for this review? reports published in the acientlilc literature on animals ant man, and my own atutiea.
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From page 264...
... There is a direct association between the amount of EEG fast waves with behavioral restlessness and the amount of EEG slow waves with stupor and cognitive defects. At "toxic" doses, patients are in stupor or coma, with rapid heart rate and lowered blood pressure.
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From page 265...
... , the stupor wee relieved ant the EEG shower decreases in both the low ant high frequencies (1, 7 ~ 31) ~ After acute administration of various compounds, the time for recovery varies with lose -- at low tones, the peak effects on parenteral administration are seen in 0.5 h and last for up to 6 h; at high doses, the effects persist for up to 24 h; at toxic doses, there is a return to baseline values the second day after administration.
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From page 266...
... Conaiderlag the many hundred a of patlenta 90 created and the continuation of this form of therapy in patients in eastern Europe today, it is unlikely that there is a behavioral syndrome of toxicity. Focusing exclusively on the anticholinergic properties of the drugs examined in military volunteers, considering the low doses used and the minimal exposures, ant aware that heroic doses of ant!
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From page 267...
... T.M. 1966 : Quantltative EEG changea induced by anticholinergic druga and their behavioral correlates in man.
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From page 268...
... and Hellerio, F 1978: Apport de la correlation electroencephalographie~clinique ~ 'activi te anticholinergique centrals de la phy sostigmine.
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From page 269...
... Chemical Corps Medical Laborat vies Contract Report #59.
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From page 270...
... ant Hayes, A Ho Acropine, acopolaotine ant Di ban: Comparati~re phaneacology ant antagoniats ln man.
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Key Terms

  • atropine toxicity
  • eeg patterns
  • slow waves
  • brain function
  • behavioral effects

  • anticholinergic compounds
  • eeg records
  • heart rate
  • fast waves
  • tic drugs

  • toxic doses
  • military volunteers
  • anticholinergic druga
  • low doses
  • baseline values

  • cognitive defects
  • toxic syndrome
  • normal limits
  • anticholine tic
  • produce adverse

  • toxicity therapy
  • heroic doses
  • clinical experience
  • defined toxic
  • edgewood arasnal

  • antidepresasats imipramine
  • medical laborat
  • focusing exclusively
  • patterns exhibit
  • epileptic spike


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