Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents Volume 1 (1982) / Chapter Skim
Currently Skimming:
Appendix K: Biochemical Aspects of Anticholinergic Chemicals-- by John J. O'Neill, Ph.D.
Appendix K: Biochemical Aspects of Anticholinergic Chemicals-- by John J. O'Neill, Ph.D.
Pages 271-274
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 271... ...
This suggests that, although events relates to muscarinic receptor action are blocked by antimnacarinic drugs, other actions may be stimulated. It is known that calcium ions activate phospholipase-C and stimulate the turnover of phoapholiplds, such as triphosphoinooltides, in excitable membranes.
|
From page 272... ...
The absence of further reports on abuse of atropine-like drugs suggests that their abuse by the volunteers in question does cot constitute a long-tens problem e Administration of atropine or scopolamine to animals increases acetylcholine output from the exposed cerebral cortex Waldo This has led to the hypothesis of a direct effect on presynaptic muscarinic receptors that regulate ACh release. The finding of release when Ca2+-free Ringer's solution is present (12)
|
From page 273... ...
Centrally, however, their actions are more complex, and pharmacodynamic and phar~acokinetlc properties play an essential roles The available evidence is not entirely convincing that their basis of central action is through postoynaptic muscarinic receptor binding,, and their pre synaptic role in calcium metabolic must be seriously considered. Without morbidity data, our present biochemical information cannot help to predict long-term effects of exposure to anticholinerglc agents.
|
From page 274... ...
and Zupanc, S 1973: Inhibition of Stlmulated Cerebral Resplration in-,ritro and Oxygen Conoumption in vlvo in Rats Treated by Cholinolytic Drugs.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.