Drinking Water and Health, Volume 9 Selected Issues in Risk Assessment (1989) / Chapter Skim
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Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model
Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model
Pages 171-174
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. Interroute extrapolation with physiologically based pharmacokinetics results in the information presented in Figure A-2, where four drinking water consumption patterns are simulated to produce four curves for AMEFF versus drinking water exposure concentrations.
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In addition to ingestion, inhalation exposures to compounds that volatilize indoors from various uses and cutaneous exposures from bathing and washing are important. Physiologically based pharmacokinetic modeling can be used to estimate the intake of one or more compounds under these circumstances.
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FIGURE A-2 Dose-route extrapolation for trichloroethylene from inhalation exposure of rats to drinking water exposure with four patterns of drinking water intake. Computer simulation from same physiologically based pharmacokinetic model as in Figure A-1.
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FIGURE A-3 Interspecies (rats to humans) extrapolation for trichloroethylene, based on physiologically based pharmacokinetic model of equivalent target-tissue doses (AMEFF, 940 mg/liter)
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