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Drinking Water and Health, Volume 9 Selected Issues in Risk Assessment (1989) / Chapter Skim
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Appendix B: A Model Illustrating Synergism
Pages 175-176

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From page 175...
... Drinking water standards are predicated on low-dose exposures, conditions under which the synergism data might not be duplicated. Although empirical data are lacking, some formal statistical models of the impact of joint exposure suggest that, as the dose (and the consequent effect)
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From page 176...
... At a lower dose, total toxicity with an interaction would be 18.65 and without an interaction would be 18.5. Thus, at high doses, the interaction makes an important contribution (about 15%)
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Key Terms

  • total toxicity
  • relative effect
  • drinking water
  • statistical models
  • water standards

  • joint exposure
  • consequent effect
  • lower dose
  • synergism data
  • disproportionately attenuated

  • average toxicity
  • empirical data
  • mathematical model
  • formal statistical
  • exposure suggest

  • interaction contribution
  • interaction makes
  • intended solely
  • necessarily reflects
  • low doses


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