Drinking Water and Health, Volume 9 Selected Issues in Risk Assessment (1989) / Chapter Skim
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Executive Summary
Executive Summary
Pages 3-5
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In addition, protein adducts, such as those found in the hemoglobin of red blood cells and in sperm protamine, are apparently stable for the lifetime of the cell and are thus good indicators of recent exposure. Protein adducts should be considered in the estimation of genetic or carcinogenic risk whenever they can be correlated with DNA binding, even though they themselves may play no putative mechanistic role.
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From page 4... ...
This information could be used in individual risk assessment to confirm suspected exposures, improve estimates of target tissue dose, and reveal metabolic activation and detoxification rates for specific carcinogen-DNA-adduct formation. In general risk assessment, it could be extremely valuable in estimating dosimetry and systemic distribution and in establishing possible target tissues or organs and the potential for irreversible toxicity, such as cancer, mutation, or developmental effects.
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From page 5... ...
Gerrn cell studies have suggested that protamine adducts are relevant to genetic risk assessment. · Baseline data on chemicals in drinking water that are presumed to be genetically toxic should be established, with an eye to revealing qualitative and quantitative associations between DNA adducts or protein adducts and other components of hazard identification.
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