Drinking Water and Health, Volume 9 Selected Issues in Risk Assessment (1989) / Chapter Skim
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3 Conclusions and Recommendations
3 Conclusions and Recommendations
Pages 57-60
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From page 57... ...
Risk assessments might be improved if new kinds of mathematical models can incorporate biologic data from studies of DNA damage over a range of doses to show where detoxification and DNA repair occur and reach their limits. However, such 57
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From page 58... ...
Germ cell studies have suggested that protamine adducts are relevant to genetic risk assessment. · Monitoring of the formation of DNA adducts or protein adducts among exposed humans, and among appropriate controls, holds promise for use in assessing the human risk associated with consumption of drinking water contaminated by potentially genotoxic agents.
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From page 59... ...
Although risk assessment using DNA-adduct measurements usually focuses on tumor formation, heritable effects of genetic toxicants should be considered a major burden for the human population. A repository of tissue samples with known DNA-adduct or protein-adduct concentrations should be established, from which a calibration process might be developed.
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