Biologic Markers in Reproductive Toxicology (1989) / Chapter Skim
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10. Conclusions and Recommendations
10. Conclusions and Recommendations
Pages 141-146
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From page 141... ...
, which might or might not be associated with fertility status, and heritable genetic damage. Chromosomal and genie abnormalities in parental germ cells may lead to reduced fertility, early or late pregnancy loss, congenital malformations, or other defects and diseases in the offspring, some of which may not have a health effect until later in adult life.
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From page 142... ...
A medical history and a physical examination, although important, are unlikely to detect exposure to a variety of toxic chemicals or effects on male reproduction. However, case reports that tentatively link infertility or abnormal reproductive outcome with particular occupations, chemicals, exposures, or drugs might be valuable indicators that lead to identification of new human male reproductive toxicants.
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From page 143... ...
· Continue basic research on mechanisms of intratesticular communication among Leydig, Sertoli, and germ cells with the goal of identifying additional markers of testicular function. · Compare the toxic responses of human and laboratory animal germ cells, to identify useful laboratory animal models of human effects.
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From page 144... ...
, and perform detailed doseresponse evaluations in animal models and extrapolate the results to humans. IDENTIFICATION OF MARKERS OF GERMINAL GENETIC TOXICITY AND HERITABLE MUTATIONS Recommendations for research needs in the development of markers of germinal genetic toxicity and heritable mutations include studies with human and animal tissues: · Study whether integration and excision of transposable elements constitute one mechanism for inducing germinal mutations.
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From page 145... ...
· Develop additional animal models for studying the role of toxic chemical metabolism, the mechanism of toxic-chemical damage, and repair mechanisms in the induction of germinal and heritable mutations. · Develop and validate human semen markers of genetic toxicity and induced mutations, including methods for detecting gene mutations, aneuploidy, chromosomal aberrations, and DNA adducts in mature sperm and in immature germ cells.
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From page 146... ...
· Serve as a clearinghouse for data analM'4LE REPRODUCTIVE TOXICOLOGY ysis and evaluation of a marker of specificity, sensitivity, precision, and accuracy in reflecting exposure to toxic chemicals and the effects of exposure on reproductive function or heritable genetic damage in laboratory animals.
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