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Biologic Markers in Reproductive Toxicology (1989) / Chapter Skim
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16. Conclusions and Recommendations
Pages 197-202

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From page 197...
... Epidemiologic studies need to be designed carefully because of the large effort involved in collecting data, particularly if a study entails biologic assays. Nested designs might be appropriate to test questions involving intensive laboratory assessments or involving only special exposure conditions (NRC, 1985~.
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From page 198...
... Environmental health research could be incorporated into current assessments of clinical populations and studies directed at answering biologic questions. Valuable information regarding the potential utility of biologic markers could be developed by integrating assessment of environmental exposures and tests for various biologic markers into existing work with populations undergoing in vitro fertilization, artificial insemination, prenatal diagnosis, and normal obstetric care.
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From page 199...
... Maternal lymphocytes + Fetal cells + Chromosomal aberrations Maternal serum + Abortus tissue + Chorionic villi + Amniotic cells + Fetal serum + Micronuclei Maternal blood Vaginal/cervical cells Fetal liver cells Fetal lymphocytes Specific-locus mutations Development/aging Onset of puberty Clinical observation, breast bud development Blood Melatonin DHEA-S Gonadotropin (pulsatile) Age of first menstrual bleeding Hormones: estrogens, inhibin, LH, FSH, androgens Age of breast development Sexual behavior Neurotransmitters in CSF Menstrual cycle length + + + + + + + + + + + +
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From page 200...
... Basal body temperature Thermometer + + + + Improved, self-recording, electronic thermometer Cervical mucus Sexual behavior Vaginal cytology Biophysical measurements of vaginal secretions Endometnal histology End o cnnolog;y: go na d o t repins, steroids, ovulatory hormones + In vitro assays LH-FSH Pituitary cells (from cadavers) Granulosa cells Luteal-specific proteins, endometnal cell cultures Mucus production, endocemcal cells Fertilization, Implantation, and Loss hCG EPF PEP + + + + + + + + + + + + + + + a + = not ready for application in humans.
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From page 201...
... ensures that males do not retain female sex accessory organs. In the neonatal male rat, testosterone secretion on the first postnatal day permanently alters the size of hypothalamic nuclei; testosterone does not have this effect after postnatal day 5.
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From page 202...
... NATIONAL DATA BASE A national data base should be developed to obtain information on human reproductive biologic markers in normal and exposed populations. Several major clinical centers could supply information to help to develop national reproductive profiles.
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Key Terms

  • reproductive toxicology
  • field studies
  • epidemiologic studies
  • exposed populations
  • germ cells

  • female reproduction
  • fetal serum
  • heart disease
  • collecting data
  • maternal serum

  • female reproductive
  • menstrual cycles
  • menstrual cycle
  • environmental exposures
  • postnatal day

  • fetal lymphocytes
  • corpus luteum
  • sexual behavior
  • ivf centers
  • clinically inapparent

  • luteal function
  • national data
  • maternal lymphocytes
  • ovulatory function
  • link information

  • evaluate ovulatory
  • vice valuable
  • medical conditions
  • functional corpus
  • biologic assessments


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