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Biologic Markers in Reproductive Toxicology (1989) / Chapter Skim
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18. Molecular Biology: Developing DNA Markers of Genotoxic Effects
Pages 211-214

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From page 211...
... DETECTING HERITABLE GENETIC DAMAGE One of the most interesting innovations in prenatal diagnosis is the use of DNA probes that reveal genetic markers near 211 specific genes (McDonough, 1985) (Table 18-1~.
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From page 212...
... A1though revolutionary developments in DNA probes have enormous potential as biologic markers in prenatal diagnosis, many challenges lie ahead. MARKERS OF EXPOSURE With the rapid development of monoclonal antibodies, radioimmunoassays, and molecular genetic technologies, new techniques have been developed to detect toxicants covalently bound to DNA to form adducts (Wogan and Gorelick, 1985; Perera, 1986; Wogan, 1988~.
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From page 213...
... In humans, assessment of in utero exposure to DNA-damaging agents has been attempted by comparing SCE frequencies in blood from mothers and their offspring. A case report from Sweden described increased SCEs in four children of two laboratory technicians who worked during pregnancy (Funes-Cravioto et al., 1977~.
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Key Terms

  • prenatal diagnosis
  • genetic markers
  • cord blood
  • deficiency results
  • muscular dystrophy

  • adrenal hyperplasia
  • duchenne muscular
  • congenital adrenal
  • sce frequencies
  • utero exposure

  • birthweights found
  • aberrations possibly
  • current assays
  • factor viii
  • monogenic disorder

  • enormous potential
  • growth hormone
  • biologic markers
  • oligonucleotide probes
  • lie ahead

  • prove amenable
  • heterozygous states
  • sample directly
  • cut dna
  • nonsmoking mothers

  • conditions caused
  • sce frequency
  • laboratory technicians
  • covalently bound
  • toxicants covalently


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