Biologic Markers in Reproductive Toxicology (1989) / Chapter Skim
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2. Introduction
2. Introduction
Pages 39-42
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From page 39... ...
that may cause disease later in life and be passed on to future generations. BIOLOGIC MARKERS OF MALE PHYSIOLOGIC DAMAGE Biologic markers of male reproductive physiology have at least four major applications, as follows: · Development and evaluation of safe and acceptable male contraception methods would be greatly facilitated by the existence of reliable biologic markers of normal male reproduction.
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From page 40... ...
· Comparable markers in animals and human beings would provide a quantitative means for extrapolating animal data to man and would allow investigations of physiologic and toxicologic mechanisms. The development and validation of markers for human male reproductive health typically require a multidisciplinary approach that includes basic research in animal and human reproductive biology, engineering and statistical development of automated and quantitative procedures, clinical studies of human factors that affect variation and of the predictive value of individual markers, and epidemiologic studies of populations exposed to xenobiotic agents.
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From page 41... ...
These innovations promise the increased sensitivity needed to detect genetic defects in the germ cells of small cohorts of mutagenized people. Germinal mutations are rare events and, as described in Chapter 9, the development of human assays for measuring genetic damage in germ cells presents special validation challenges, including a precise understanding of the spectrum of mutational damage detected, as well as an understanding of underlying mechanisms and assay responsiveness.
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From page 42... ...
Sensitive detection methods would benefit studies of both animals and humans and ultimately the assessment of human germinal risk. ORGANIZATION OF MALE REPRODUCTION SECTION This section evaluates markers that could be used to assess reproductive effects of pathophysiologic changes and heritable genetic damage in males.
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