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Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants Volume 1 (1994) / Chapter Skim
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B10: Trimethylsilanol
Pages 177-184

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From page 177...
... Johnson Space Center Toxicology Group Biomedical Operations arm Research Branch Houston, Texas PHYSICAL AND CHEMICAL PROPERTIES Trime~ylsilanol (TMS) is a volatile liquid wig He following properties (Rouviere, 1973)
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From page 178...
... In a study in which TMS was administered orally to rats at doses of 33 and 100 mg/kg/d for 31 it, there was no evidence of TMS or organosoluble silicon metabolites In blood, liver, or Honeys or of silicon in urine beyond 48 h following He last dosing (Dow Corning Corp., 1972~. TOXICITY SUMMARY Acute and Short-Term Studies Inhalation studies of He toxicity of TMS have not been conducted in animals or humans (Dow Corning Corp., 1991)
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From page 179...
... Subchronic and Chronic Studies In a study in which TMS was administered by gavage once daily for 5 d/w for 2 w to four groups of male Sprague-Dawley rats (number unspecified) at doses of 0, 250, 500, or 750 mg/kg/d, no significant toxic or adverse effects, including behavioral changes, gross pathological changes, or effects on food consumption or body or organ weights, were observed at the lowest TMS dose of 250 mg/kg/d (Dow Corning Corp., 1983~.
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From page 180...
... IS0 SMACK' FOR SELECTED AIRBORNE CONTAMINA=S Genotoxicity Results of in vivo bone marrow cytogenic assays indicate Mat TMS is not genotox~c at doses of 100-500 mg/kg administered ip to rats (Isqui~ et al., 1988~. The lack of significant ciastogenic potential of TMS also was evident in a rodent dominant legal test in which oral doses of 20-200 mg/kg/d, 5 d/w for ~ w had no effect on fertility index, pre-implantation loss, or fetal resorptions in the rat (Isqui~h et al., 1988~.
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From page 181...
... 181 an C)
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From page 182...
... effects, was 250 mg/kg/d (Dow Corning Corp., 1983~. A more sensitive NOAEL comes from ip and iv studies in which single injections of 100 or 200 mg/kg induced light or moderate anesthesia (Dow Corning Corp, 1991~.
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From page 183...
... exposure. That threshold was determined from the rat oral data, assuming a species factor of 10, a body weight of 70 kg, and a breathing volume of 15 L/min.
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From page 184...
... Dow Corning Internal Research Report Summary. Dow Corning Corp., Midland, Mich.
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Key Terms

  • corning corp
  • light anesthesia
  • internal research
  • food consumption
  • breathing volume

  • organ weights
  • lithium derivative
  • cns depressant
  • research report
  • organ weight

  • guinea pig
  • clinical blood
  • blood chemistry
  • oral dosing
  • significant alterations

  • administered orally
  • pathological changes
  • depressant effects
  • oral doses
  • body weight

  • weight ratios
  • corning internal
  • smac values
  • species extrapolation
  • clinical anesthesia

  • report abstract
  • inhaled tms
  • moderate breathing
  • interactive effects
  • histopathological changes


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