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Permissible Exposure Levels for Selected Military Fuel Vapors (1996) / Chapter Skim
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12 Effects of Military Fuels on the Eyes and Skin
Pages 104-108

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From page 104...
... DERMAL AND OCULAR EFFECTS OF JP-4 FUEL In studies using rabbits and guinea pigs, ICinlcead et al.
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From page 105...
... Dermal irritation was evaluated using the Draize scoring technique 3 days following application of 0.5 mL of diesel fuel to abraded and nonabraded skin of three male and three female New Zealand White rabbits. Based on the Draize scoring measures, the primary de rmal- irritation index was 6.S extremely irritating.
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From page 106...
... Based on the Draize measures, the primary dermal-irritation index was 1.29 slightly irritating. Dermal sensitization was assessed following topical application of 0.l mL of JP-S to the clipped flanks of 10 Hartley male albino guinea pigs four times over a 10-clay period.
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From page 107...
... Dermal sensitization was assessed in 20 Hartley male albino guinea pigs using the modified Landsteiner test. Animals received seven 0.~-mL intradermal injections of a 0.01% solution of DFM in peanut of} in the lumbo-sacral area over a 15-day period.
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From page 108...
... Dermal sensitization was assessed in 20 Hartley male albino guinea pigs using the modified Landsteiner test. Animals received seven 0.~-mL intradermal injections of a 0.01% solution of JP-5 in peanut of} in the lumbo-sacral area over a 15-clay period.
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Key Terms

  • zealand white
  • ocular irritation
  • dermal irritation
  • dermal sensitization
  • guinea pigs

  • irritation resulting
  • diesel fuel
  • investigated dermal
  • following application
  • draize scoring

  • scoring technique
  • nonabraded skin
  • irritation following
  • six female
  • male albino

  • evaluated using
  • hartley male
  • days following
  • albino guinea
  • clipped flanks

  • following challenge
  • conjunctival sacs
  • draize technique
  • scored using
  • studies performed

  • body surface
  • assessed following
  • topical application
  • pigs using
  • examined using


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