Permissible Exposure Levels for Selected Military Fuel Vapors (1996) / Chapter Skim
Currently Skimming:
5 Effects of Military Fuel Vapors on the Kidney
5 Effects of Military Fuel Vapors on the Kidney
Pages 44-50
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 44... ...
Pertinent data available on the Iciclney toxicities of JP-5 fuels, JP-8 fuels, and DFM in animals are summarized in this chapter. EFFECTS OF ACUTE EXPOSURES TO FUEL VAPORS Few studies have a(lclressed the toxicity associated with exposure to diesel fuel.
|
From page 45... ...
The presence of hyaline droplets in the Icidneys correlated with an accompanying rise in serum creatinine and blood urea nitrogen (BUN) , signs of functional kidney ciamage Parker et al., ~ 98 I; Bogo et al., ~ 983~.
|
From page 46... ...
Male and female F344 rats and male and female C57BLi6 mice were exposed for 90 days to JP-8 vapor at airborne concentrations of 500 or 1,000 mgim3. After the 90-day exposure, a "triad" of lesions was described in the kidneys of male rats: dramatically exacerbated hyaline droplet formation, granular casts in the outer medulla, and an increased incidence and severity of lesions undifferentiable from those of chronic progressive nephrosis.
|
From page 47... ...
Renal epithelial tubular cell necrosis appeared to occur at the same incidence with the two fuels. Female rats were free of any significant Icidney injuries, as were female mice.
|
From page 48... ...
The lesions appeared to be located before the pars recta of the proximal tubules descended into Henie's loop. There was a mariced increase in cytoplasmic hyaline droplets in the proximal tubular cells throughout the renal cortex.
|
From page 49... ...
Table 5-l summarizes the {ciciney toxicity of these military fuels. CONCLUSIONS The {kidney lesions seen in male rats exposed to JP-5, IP-8, and DFM vapors resemble a lesion Known as oc2u-giobulin nephropathy.
|
From page 50... ...
50 at · At · cn o · · o .o .~ rat do 1 Em a' at a; at au ~ At to ~ i .~:3 At o ~ o mo _ Cat ~ ·o ._ ~ - ; ~ a; an; — Cut ~ Go Cat of .^ ~ a; 0 ~ ~ ~ ~ o.u .
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.