Possible Long-Term Health Effects of Short-Term Exposure To Chemical Agents, Volume 2 Cholinesterase Reactivators, Psychochemicals and Irritants and Vesicants (1984) / Chapter Skim
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Appendix A. History of the Edgewood Testing Program; Volunteer Screening and Selection
Appendix A. History of the Edgewood Testing Program; Volunteer Screening and Selection
Pages 256-262
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From page 256... ...
As the program developed, it became customary to test agents at dose increments of 40 percent, once the approximate effects of the lower doses were known. Placebos were used in some studies, but the cost with respect to subject confinement time, staff workload, and delay in achieving estimates of potency made this impractical except in special casses ~ e .
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From page 257... ...
Many other extrapolation techniques have been used in manipu~ation of animal lethality data in an effort to generate a reasonable human estimate. By taking a conservative approach with data on deaths at low doses, one can derive estimates for man that are modest and in keeping with clinical judgement.
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From page 258... ...
2. Mark profiles borderline and carefully examine family history for indication of psychological problems ifa.
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From page 259... ...
Other items: Blow rate of promotion, lack of clear cut goals, excessive depreciation of self value, and generally bizarre answers -25g
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From page 260... ...
At the time of the screening interview, on the basis of the interview, history, questionnaire (sentence completion and Picture Frustration tests) and MMPI scores a rating will be applied to each candidate to separate out the following groups and an entry will be made upon the Physical Examination sheet opposite the heading "Psychiatric" characterizing the candidates qualification for drug testing, as follows: Rating A B C D Qualification (on PE form)
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From page 261... ...
~ ~ _. : :or _ may be somewhat dull or non-verbal, have obvious neurotic traits, immaturity, rigidity or other apparent liabilities, but with good reality assessment and no borderline or psychotic tendencies at present or at any time in past history does not include bizarre circumstances or severe and cont inued traumatization.
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From page 262... ...
if adherence would interfere with the accomplishment of a particular investigation, as, for example, a study of the effects of psychochemicals upon depressed subjects. But the conditions of such an experiment would demand an unusual attention to the safety and wellbeing of the volunteers selected.
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