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Health Risks from Exposure to Low Levels of Ionizing Radiation BEIR VII, Phase I, Letter Report (1998) / Chapter Skim
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Pages 1-11

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From page 1...
... 334-2232 FAX (202) 334-1639 The Environmental Protection Agency Office of Radiation a~nd indoor Air asked the National Research Council to evaluate whether sufficient new data exist to warrant a reassessment of health risks reported in Health Effects of Exposure to Low Levels of Ionizing Radiations (BEIR V)
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From page 2...
... Further knowledge of these mechanisms that should become available in the next 3 years might affect estimation of the radiation-response curve at low doses. · Over the next few years, investigators will be applying two closely linked approaches using animal models of carcinogenesis.
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From page 3...
... Information on such phenomena as DNA repair, signal transduction, chromosomal instability, and adaptation, although preliminary, might eventually affect risk analyses of low-dose and low-dose-rate exposures. The committee recommends that the group responsible for the proposedlphase 2 study · Include a comprehensive review of all relevant epidemiologic data related to lowI~ET (low linear energy transfer)
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From page 4...
... With respect to modleling, the committee recommends that the group responsible for the proposed" phase 2 study · Develop appropriate risk models for major cancer types and other outcomes, including benign disease and genetic effects. Specifically, the responsible group should develop models appropriate for probability-of-causation tables and should consider the fitting of purely empirical models to original data from studies or combined studies, the fitting of purely empirical models with meta-analytic techniques, and the fitting of semiempincal biology-based models to epidemiologic data.
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From page 5...
... To accomplish the above charge, the membership of the group responsible for the proposed BEIR VII phase 2 study will require expertise in epidemiology, biostatistics, radiation physics and dosimetry, molecular biology, risk assessment, cancer modeling, arumal and cellular radiation biology, somatic cell genetics, cell-cycle regulation and apoptosis, and ionizing radiation-induced DNA damage and its repair. The committee recommends that the experts chosen have adequate resources and access to data for the computing, statistical analyses, and modeling required to complete the study.
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From page 6...
... :, study. Although not exhaustive, the list should serve as a guide to some of the pertinent new and upcoming epidemiologic data on the subject.
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From page 7...
... Rad Res 1997;147:385-395. YEARS OF FOLLOW -UP 19351992 19351992 CANCER SITES REPORTED All cancer and multiple cancer sites Leukemia 19501987 19581987 19581989 Leukemia, lymphoma, multiple myeloma Multiple cancer sites (solid tumors)
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From page 8...
... Rad Res 1996;145:694-707. Cohort Cohort Mortality Mortality Male and Female Female 64,172 31,917 YEARS OF FOLLOW -UP 1 9501987 1 9501987 CANCER SITES REPORTED Lung cancer Breast cancer Cervical cancer patients Storm et al.
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From page 9...
... Cohort Incidence Incidence Male and Female Male and Female 120,000 544 19261990 19391991 Thyroid cancer Benign thyroid nodules Radiation treatment for benign head and neck conditions (thyroid cancer and thyroid nodules) CohortIncidence Male and Female 4,296 19391990 Thyroid cancer and nodules Radiation treatment for breast cancer Radiation treatment for peptic ulcer Curtis et al.
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From page 10...
... Mortality following Cohort Mortality Female 816 1925 infertility radiation treatment for infertility of 1991 hormonal origin or amenorrhea. Int J Cancer 1994; 23:1165-1173 CANCER SITES REPORTED Breast cancer Multiple cancer sites (gastrointestinal only)
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From page 11...
... l childhood cancer from fetal irradiation, Brit J Radiol 1997; 70:130-139 11
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Key Terms

  • rad res
  • cancer mortality
  • thyroid cancer
  • cancer sites
  • beir vii

  • multiple cancer
  • radiation treatment
  • vii phase
  • low doses
  • ionizing radiations

  • epidemiologic data
  • natl cancer
  • cancer inst
  • proposed beir
  • bomb survivors

  • health risks
  • mortality following
  • atomic bomb
  • lung cancer
  • benign thyroid

  • ionizing radiation
  • contralateral breast
  • radiation induced
  • thyroid disease
  • risk models

  • survivors study
  • risk estimation
  • rate ionizing
  • interview study
  • benign disease


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