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Letter Report - Review of Analysis Plan for the Hanford Thyroid Disease Study (HTDS) (1998) / Chapter Skim
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Contents of Report
Pages 1-6

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From page 1...
... This addendum to the June 30, 1997 analysis plan described above addresses the two topics reviewed by the Research Council committee: (~) How the HTDS analysis will deal with information about exposures of study participants to iodine-131 released mom the Nevada Test Site (NITS)
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From page 2...
... The original plan has been reviewed bv He Radiation Studies ranch or tne Centers tor Disease Control arid Prevention, by several ad hoc peer reviewers, and by the Hanford Thyroid Disease Study Advisory Committee. I-he comunents of those varied reviewers were shared with the committee, arid the HTDS investigators' responses to them were presented in writing.
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From page 3...
... As noted earlier, two specific challenges to He investigators are He development of an analytic plan to take into account the additional thyroid dose to Hanford study subjects emanating Tom NTS fallout and He uncertainty In the dose estimates. ~ the course of He committee's review of these two issues, the committee recommended Cat the HODS consider an alternative analysis that allows somewhat better control for age at irradiation.
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From page 4...
... In pnnciple, the HTDS could apply the National Cancer Institute (NCI) dose data in their current form for the relevant exposure period of individuals or groups, report the total thyroid risk for these individuals Or groups, arid provide the fractional contribution of the NTS fallout to the total risk.
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From page 5...
... Dose Uncertainly: l~ughout the analysis aIld interpretation of the HTDS data, the limitations of He dose tenn must be acknowledged. The HTDS Investigators are cognizant of this and have incorporated many safeguards against systematic error into the study, but the resulting dose estimates are highly uncertain, and He use of self-reported information in the construction of He dose estimates presents an opportunist for bias.
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From page 6...
... Schull Chairman Committee on an Assessment of CDC Radiation Studies s:s cc: Dr. Evan Douple (BRER' Study Director)
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Key Terms

  • htds analysis
  • thyroid disease
  • nts doses
  • nts fallout
  • htds investigators

  • hanford thyroid
  • confounding variable
  • disease study
  • dose estimates
  • radiation studies

  • analytic plan
  • htds doses
  • nts data
  • estimated doses
  • thyroid risk

  • study participants
  • persons living
  • thyroid dose
  • cdc radiation
  • total risk

  • individual doses
  • test site
  • nevada test
  • original plan
  • study subjects

  • radiation dose
  • hanford site
  • exposure age
  • studies branch
  • cancer institute


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