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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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Supraspinal Contributions to Hyperalgesia
Pages 7687-7692

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From page 7687...
... For example, high-intensity electrical stimulation or high-dose glutamate or neurotensin injection into the RVM inhibits spinal nociceptive transmission via descending projections in the dorsolateral funiculi and activation of spinal cholinergic and monoaminergic receptors. In contrast, facilitatory influences from the RVM produced by electrical stimulation, glutamate injection, or neurotensin injection involve descending projections in the ventrolateral funiculi and are mediated by spinal serotonin and cholecystokinin receptors.
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From page 7688...
... Effect Tactile allodynia, foot Enhanced excitability of WDR dorsal horn neurons Facilitation of the thermal tail-flick reflex Enhanced C-fiber-mediated flexor motoneuron wind-up Facilitation of the thermal paw-withdrawal response Facilitation of the thermal paw-withdrawal response Facilitation of the thermal tail-flick reflex Tactile allodynia, foot Tactile allodynia, foot Facilitation of the thermal paw-withdrawal response Tactile allodynia, foot Facilitation of the thermal tail-flick reflex Spinal transection Intra-RVM lidocaine Spinal transection Intra-RVM lidocaine Spinal transection Electrolytic RVM lesion Ibotenic acid RVM lesion Spinal transection Intra-RVM lidocaine Ibotenic acid RVM lesion Intra-RVM lidocaine Ibotenic acid RVM lesion Spinal transection Electrolytic RVM lesion Intra-RVM lidocaine Spinal transection Spinal transection Ref. Block Block 26 27 Block 28, 29 Block 37 Block 29 No effect 29 block 41, 42 Block Block Block Electrolytic RVM lesion Block Electrolytic NTS lesion 44 45 46 42 , 50
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From page 7689...
... Similar to what was seen in the model of mustard oil hyperalgesia, both NADPH-diaphorase-labeled cell numbers and the number of cells immunostained for the neuronal isoform of NO -synthase were significantly increased in the RVM 3 hr after colonic inflammation. These results support a role for descending facilitatory influences in the maintenance of mustard oilinduced and visceral hyperalgesia involving activation of NMDA and neurotensin receptors in the RVM.
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From page 7690...
... The studies reviewed here all have examined behavioral consequences of peripheral tissue insult, and there are limited data available yet with respect to the direct influence of the RVM on spinal neuron plasticity (central sensitization)
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From page 7691...
... In contrast, primary hyperalgesia does not involve descending facilitatory influences from supraspinal sites and is likely the direct result of peripheral nociceptor sensitization and neuroplasticity intrinsic to the spinal cord. For clarity, the afferent input to the spinal dorsal horn from the site of injury is illustrated as not entering the spinal cord (which it certainly does)
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From page 7692...
... 7692 Colloquium Paper: Urban and Gebhart Coutinho, S V., Urban, M
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Key Terms

  • facilitatory influences
  • spinal cord
  • mustard oil
  • central sensitization
  • descending facilitatory

  • thermal hyperalgesia
  • dorsal horn
  • spinal transection
  • rvm lesion
  • ibotenic acid

  • supraspinal sites
  • spinal dorsal
  • receptor antagonist
  • spinal nociceptive
  • nociceptive transmission

  • spinal neuron
  • primary hyperalgesia
  • neuropathic pain
  • secondary thermal
  • peripheral tissue

  • carrageenan injection
  • nmda receptor
  • tissue injury
  • prevented facilitation
  • acid rvm

  • tissue insult
  • peripheral inflammation
  • peripheral injury
  • inhibitory influences
  • horn neuron


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