(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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The Postnatal Development of Spinal Sensory Processing
The Postnatal Development of Spinal Sensory Processing
Pages 7719-7722
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From page 7719... ...
The study of the neurophysiological properties and connectivity of sensory neurons in the developing spinal cord dorsal horn of the intact postnatal rat has shed light on the way in which the newborn central nervous system analyzes cutaneous innocuous and noxious stimuli. The receptive field properties and evoked activity of newborn dorsal horn cells to single repetitive and persistent innocuous and noxious inputs are developmentally regulated and reflect the maturation of excitatory transmission within the spinal cord.
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From page 7720... ...
Background activity is generally absent when neonatal cells are initially isolated for recording, but strong responses can be evoked by mechanical stimulation of the skin of the receptive field. Some cells respond to both innocuous brushing and noxious pinching of the skin, but the convergence of input to dorsal horn cells changes over the postnatal period (Table 1~.
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From page 7721... ...
Representations of the peripheral receptive fields. Those in black represent cells receiving afferents from inflamed skin, whilst those in grey are the control.
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From page 7722... ...
Dev. Brain Res.
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