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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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Does a Neuroimmune Interaction Contribute to the Genesis of Painful Peripheral Neuropathies?
Pages 7737-7738

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From page 7737...
... Neuropathic animals react with a large and prolonged withdrawal response (painful peripheral neuropathy patients with cold-allodynia complain that this stimulus produces a severe burning pain sensation)
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From page 7738...
... , the neuritis-evoked neuropathic pain may prime the nervous system such that pathogenic mechanisms that develop later (e.g., spontaneous ectopic discharge in injured nociceptors, sprouting sympathetic efferent axons in the dorsal root ganglia, A-~3 low-threshold mechanoreceptors invading laminae I and II) are able to produce chronic neuropathic pain.
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Key Terms

  • hind paw
  • inflammatory stimulus
  • painful peripheral
  • produces neuropathic
  • peripheral neuropathies

  • abnormal pain
  • nerve injury
  • tumor necrosis
  • necrosis factor
  • focal neuritis

  • ipsilateral hind
  • structural damage
  • neuritis model
  • injured nociceptors
  • stimulus produces

  • neuroimmune interaction
  • cci model
  • ectopic discharge
  • dorsal root
  • pathogenic mechanisms

  • pain sensations
  • neuritis produces
  • root ganglia
  • short duration
  • reprint requests

  • cci nerves
  • endoneurial inflammatory
  • abnormal sensitivity
  • metabolic disease
  • peripheral neuropathy


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