Biographical Memoirs Volume 77 (1999) / Chapter Skim
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Alwin Max Pappenheimer, Jr.
Alwin Max Pappenheimer, Jr.
Pages 264-281
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tells us so much about this unique man. As a young investigator Pap cleliberately set himself the ciaunting task of unraveling the intricate mechanism of an infectious process in precise biochemical terms.
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I remember Jacques Loeb the physiologist; Gary Calkins, professor of biology at Columbia University; Alfred Redfield, who took us sailing and later became professor of biology at Harvard; and Michael Heidelberger, who lived next door, played the clarinet, and who years later stimulated my early interest in immunology and immunochemistry. There was a summer school at Woods Hole where I learned to catch and mount butterflies and moths and to raise them from caterpillars.
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Conant reacliTy acceptec! Pap as a graduate student despite his frank avowal that he was not interested in becoming a chemist but wisher!
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to Cambridge, Massachusetts, in 1935 without a job but happy nonetheless that he had finally chosen a problem he wantec! to solve, in his own words, simply "to isolate a pure potent bacterial toxin en c!
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on to establish its purity by excluding contaminating proteins immunologically using the toxin-antitoxin flocculation reaction, which shower! the toxin to be at least 95% pure.
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Colin's offer promptly and happily, because he and Colin shared the same icleas about what a new department of bacteriology should be like and because he was intrigued by the excitement of Colin's work on the pneumococcal transforming principle with Avery and McCarty at the Rockefeller Institute. The only stipulation that Pap hac!
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then Jonathan Uhr, Matthew Scharff, Sam Salvin, en c! William Kuhns all were studying various phases of the immune response to cliphtherial antigens, a task that resultec!
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ciarinetist and violist himself, Pap fostered chamber music concerts at Dunster House, an innovation for which it became notes!
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the ADP-ribosylation reaction by which diphtheria toxin inactivated EF-2. Jack Murphy working with Pap in 1974-75 began studies on the transcriptional regulation of the fox gene, en c!
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Pappenheimer, Jr.," and was published in Cellu[ar Immunology.3 As the late Lewis Thomas aptly remarket! in an appreciation of Pap at that symposium, "Pap had a powerful influence on a great many younger people, setting in place the very course of the whole scientific careers of many of them.
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Most recently, together with his former student John Collier, he receiver! the Paul Ehrlich Prize en c!
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M Pappenheimer, Tr., which had been submitted for publication to Protein Science, but which did not appear in the edited publication, and for permission to quote from a portion of Pappenheimer's unpublished remarks titled "Some Reminiscences
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N.B. Original manuscript that formed the basis of the condensed edited publication cited in Note 1 above.
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II. Production of potent toxin on a simple amino acid medium.
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III. Specific desensitization of guinea pigs sensitized to protein antigen.
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II. Kinetic studies on intoxication of HeLa cells by diphtheria toxin and related proteins.
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