Biographical Memoirs Volume 77 (1999) / Chapter Skim
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Walther Frederick Goebel
Walther Frederick Goebel
Pages 96-107
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Michael Heiclelberger at the Rockefeller Institute for Meclical Research in their seminal work on the nature of the soluble specific substances of the pneumococcus. Their studies hac!
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The title "member" was replaced by "professor" in 1957, after the institute initiated a predoctoral program and was renamed Rockefeller University. He became professor emeritus in 1970 on reaching the age of seventy.
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Alice Lawrence Behn in 1976 en c! spent his remaining life in retirement in Greenwich, Connecticut.
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. Avery and his coworkers had found that this type-specific immunity was referable to a "soluble specific substance" present in the capsule surrounding the pneumococcal cells.
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Starch, on the other hancI, is a polysaccharicle macle up of numerous glucose molecules. There are a large number of different simple sugars, thus providing for a wicle variety of diverse polysaccharicles, some of which have four or more different simple sugar components.
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returned to a study of the type III pneumococcal polysaccharide. He synthesized the glucose-glucuronic acid clisaccharicle en c!
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Interestingly, in a brief assessment of his "discoveries" fount! in the biographical material on file at the National Academy of Sciences' membership office, Goebel cites only the studies on the polysaccharicles
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His summary of his discoveries was as follows: These investigations indicated beyond question that it is the precise chemical structure of the carbohydrate, be it simple or complex, that determines its immunological specificity, a fact hitherto unknown. This personal statement of his contributions provides a concise en c!
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IV. The synthesis of the p-aminobenzyl ether of the soluble specific substance of type III pneumococcus and its coupling with protein.
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II. The chemical basis for the immunological relationship between the capsular polysaccharides of types III and VIII pneumococcus.
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69:353-64. 1940 Studies on antibacterial immunity induced by artificial antigens.
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