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The Five Series Study Mortality of Military Participants in U.S. Nuclear Weapons Tests (2000) / Chapter Skim
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7 Exposure Definition and Measurement
Pages 36-41

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From page 36...
... Initial plans for the new Five Series Study included the use of these individual dose assignments. The committee charged with oversight of the present study created a working group, with external expertise, to review DNA dosimetry estimation procedures and results.
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From page 37...
... A working group of the Five Series Study oversight committee assessed the basis and quality of the data upon which dose assignments were made and concluded that they were not suitable for dose-response analyses in epidemiology (IOM, 1995, p. 2~: The Working Group concluded that there has been a lack of consistency over time in NTPR dose estimation methods and, in particular, in the methods of assigning "high-sided" doses, that is, doses in which uncertainties are resolved in favor of assigning higher doses rather than lower doses.
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From page 38...
... We hypothesized that either the number of badges issued to an individual or the total dose derived from badge data might be a more reliable measure of individual exposure than the reconstructed total dose discussed above. Based on DNA background material, we hypothesized that the participants most likely to be exposed to ionizing radiation would have been issued more badges than those believed less likely to be exposed.
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From page 39...
... They provide descriptive information, but we believe that they are difficult to interpret because of the many unmeasured and potentially heterogeneous circumstances that they represent. Given the wealth of anecdotal and written record descriptions of potential high-dose situations (e.g., troops involved in maneuvers such as Desert Rock Troop Brigades; those involved in cloud sampling; and radiation safety personnel)
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From page 40...
... The participant versus referent cohort dichotomy provides the largest group of people to study, size being important when considering rare outcomes such as leukemia. Using participant status to represent exposure in this case, potential exposure to ionizing radiation and possibly to other testrelated environmental factors also presents many limitations regarding epidemiologic study.
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From page 41...
... For reasons explained in detail in its earlier report (IOM, 1995) , the oversight committee believes that useful dose reconstructions can be achieved if certain guidelines such as unbiased selection of participants and technical consistency in methodology for dose estimation are followed.
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Key Terms

  • total dose
  • five series
  • oversight committee
  • radiation dose
  • lower doses

  • test series
  • nuclear test
  • badge data
  • dose reconstructions
  • dosimetry data

  • test site
  • nevada test
  • personnel review
  • ntpr database
  • assigned dose

  • dose estimation
  • dose data
  • film badges
  • test personnel
  • badges issued

  • individual doses
  • ntpr dosimetry
  • weapons test
  • individual using
  • badged dose

  • dose assignments
  • dose assigned
  • safety personnel
  • film badge
  • assigned doses


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