The Five Series Study Mortality of Military Participants in U.S. Nuclear Weapons Tests (2000) / Chapter Skim
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11 Findings
11 Findings
Pages 61-72
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From page 61... ...
The findings from these analyses suggested additional avenues of investigation, the results of which are then reported. TESTS OF PREDETERMINED PRINCIPAL ENDPOINTS We had determined in advance of data collection that participant versus referent mortality rates would be formally compared for three endpoints all causes, all malignancies, and all leukemia minus chronic lymphoid leukemia (CLL)
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From page 62... ...
, and participants had an estimated 14 percent higher risk of leukemia death (HR = 1.14~. However, none of these hazard ratios is significantly different from 1.00, indicating that there were no statistically significant differences between the participant and referent cohorts on these outcome measures.
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From page 69... ...
Operation PLUMBBOB, for example, consisted of 30 tests, including safety tests that produced negligible yields as well as detonations of up to 44 kt (Harris et al., 1981~. A formal test of heterogeneity of leukemia minus CLL risks among the individual test series was not statistically significant (x2 = 7.191, 4 df,p = .13~; thus, we removed the series-specific analyses from the core presentation of this report.
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From page 70... ...
INVESTIGATING LEUKEMIA RISK BY TIME SINCE FIRST PARTICIPATION AND AGE AT FIRST PARTICIPATION To explore the increased, but not statistically significant, risk of leukemia observed among participants relative to referents, we looked for patterns consonant with other research findings on the association of radiation and leukemia. We therefore fit a model using time-dependent covariates to estimate the risk of leukemia death in three periods relative to first series participation: less than 5 years, 5 years to less than 15 years, and 15 years or more after participation.
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From page 72... ...
Proportional hazards model controls for series, service branch, and paygrade by stratification and age, age squared, and age cubed by covariate adjustment.
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