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Frontiers of Engineering Reports on Leading Edge Engineering from the 1999 NAE Symposium on Frontiers of Engineering (2000) / Chapter Skim
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2 Making Sense of the Human Genome
Pages 25-28

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From page 27...
... Implementation of the DNA array technology has required the integration of multiple technical disciplines resulting in the development of fabrication methods for the probe arrays, assays for the detection of target hybridization, algorithms to analyze the hybridization data, and platform instruments to support the technology. Applications of the arrays include the analysis of genetic mutations, the simultaneous expression profiling of thousands of genes, a new method to quickly discover polymorphisms of the human genome, and a new tool for genomic mapping.
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Key Terms

  • dna array
  • reviews specific
  • parallel nucleic
  • technical disciplines
  • specific oligonucleotide

  • hybridization data
  • probe array
  • array technology
  • multiple technical
  • disciplines resulting

  • fabrication methods
  • sequence data
  • directly yielding
  • nucleic acid
  • talk reviews

  • array designs
  • acid hybridization
  • hybridization analysis
  • platform instruments
  • oligonucleotide probe

  • target hybridization
  • human genome
  • quickly discover
  • simultaneous expression
  • paradigm experiments

  • oligonucleotide probes
  • combinatorial chemical
  • expression profiling
  • generate miniaturized
  • discover polymorphisms


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