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Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate (2000) / Chapter Skim
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Executive Summary
Pages 1-2

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From page 1...
... EPA did not use the mink study, which reported an increase in female mortality, citing natural high mortality in captive mink and uncertainties about the relevance of mink to human health assessment. Colorado disagreed with EPA's assessment, contending that EPA used inappropriate data to assess mortality rates in captive mink and that mink have extrapolative relevance to humans.
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From page 2...
... The subcommittee considers the 1997 two-generation reproductive study to be the best available study for deriving a drinking-water guideline, because it involved the most relevant exposure duration (13 months) and because the most biologically meaningful findings of the study, Heinz body formation (protein aggregates in ox~dativelystressed red blood cells)
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Key Terms

  • subchronic toxicity
  • reproductive study
  • captive mink
  • reproductive toxicity
  • army asked

  • particular relevance
  • citing natural
  • meaningful findings
  • extrapolative relevance
  • protein aggregates

  • studies relevant
  • mortality rates
  • comparative metabolism
  • heinz body
  • metabolism study

  • blood cells
  • female mortality
  • colorado promulgated
  • red blood
  • independent evaluation

  • body formation
  • biologically meaningful
  • exposure duration
  • health assessment
  • available study

  • appropriate database
  • whereas epa
  • subcommittee considers
  • relevant exposure
  • colorado disagreed


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