In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines:
Institute of Medicine. 1999. Assessment of Future Scientific Needs for Live Variola Virus. Washington, DC: The National Academies Press. https://doi.org/10.17226/6445.
Chapters | skim | |
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Front Matter | i-xviii | |
Executive Summary | 1-4 | |
Part I. Introduction | 5-6 | |
1 Introduction | 7-14 | |
Part II. Smallpox and Its Control | 15-16 | |
2 Variola Virus and Other Orthopoxviruses | 17-24 | |
3 Clinical Features of Smallpox | 25-32 | |
4 Epidemiology | 33-36 | |
5 Variola Virus Stocks Following Eradication of Smallpox | 37-44 | |
Part III. Scientific Needs for Variola Virus | 45-46 | |
6 Development of Antiviral Agents | 47-52 | |
7 Development of Vaccines | 53-58 | |
8 Detection and Diagnosis | 59-62 | |
9 Bioinformatics | 63-68 | |
10 Understanding of the Biology of Variola Virus | 69-72 | |
11 Research on the Expressed Protein Products of Variola | 73-76 | |
Part IV. Findings | 77-78 | |
12 Summary and Conclusions | 79-86 | |
References | 87-92 | |
Appendix A Glossary | 93-98 | |
Appendix B Acronyms | 99-100 | |
Appendix C Committee and Staff Biographies | 101-108 |
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