The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak.
Integrating Clinical Research into Epidemic Response: The Ebola Experience assesses the value of the clinical trials held during the 2014–2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.
Table of Contents
|2 Conducting Clinical Research During an Epidemic||37-82|
|3 Assessment of Therapeutic Trials||83-112|
|4 Assessment of Vaccine Trials||113-154|
|5 Strengthening Capacity for Response and Research||155-198|
|6 Engaging Communities in Research and Response||199-222|
|7 Facilitating International Coordination and Collaboration||223-250|
|Appendix A: Study Approach and Methods||251-286|
|Appendix B: Clinical Trial Designs||287-296|
|Appendix C: Ethical Principles for Research with Human Subjects||297-300|
|Appendix D: Biographical Sketches of Committee Members and Staff||301-316|
The National Academies Press and the Transportation Research Board have partnered with Copyright Clearance Center to offer a variety of options for reusing our content. You may request permission to:
For most Academic and Educational uses no royalties will be charged although you are required to obtain a license and comply with the license terms and conditions.
For information on how to request permission to translate our work and for any other rights related query please click here.
For questions about using the Copyright.com service, please contact:
Copyright Clearance Center
22 Rosewood Drive
Danvers, MA 01923
Tel (toll free): 855/239-3415 (select option 1)
Loading stats for Integrating Clinical Research into Epidemic Response: The Ebola Experience...