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Suggested Citation:"Appendix D: Acronyms." Institute of Medicine. 2003. Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy. Washington, DC: The National Academies Press. doi: 10.17226/10649.
Page 103
Suggested Citation:"Appendix D: Acronyms." Institute of Medicine. 2003. Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy. Washington, DC: The National Academies Press. doi: 10.17226/10649.
Page 104

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Appendix D Acronyms AAP - American Academy of Pediatrics ACIP - Advisory Committee on Immunization Practices BCG - Bacillus Calmet-Guerin vaccine CDC - Centers for Disease Control and Prevention CI - confidence interval CPT - carnitine palmitoyltransferase CESDI- Confidential Enquiry into Stillbirths and Deaths in Infancy CISA - Clinical Immunization Safety Assessment CNS - central nervous system DHHS - Department of Health and Human Services DTaP - diphtheria-tetanus-acellular pertussis vaccine DTC - trivalent diphtheria-tetanus-pertussis (whole-cell) vaccine DTCP - tetravalent diphtheria-tetanus-pertussis (whole-cell)-poli vaccine DTP or DTwP- diphtheria-tetanus-whole-cell pertussis vaccine DTPP - diphtheria, tetanus, pertussis, and polio vaccine DTwPH - diphtheria, tetanus, whole-cell pertussis, and Haemophilus influenzas type b vaccine DwP - diphtheria toxoid and pertussis antigen vaccine FAO - fatty acid oxidation FDA - Food and Drug Administration 103

104 IMMUNIZATION SAFFI Y REVIEW HBeAg - hepatitis B e antigen HbOC - oligosaccharide conjugate Haemophilus influenzas type b vaccine HBsAg - hepatitis B surface antigen HepB - hepatitis B vaccine HHE - hypotonic-hyporesponsive episode Hib - Haemophilus influenzas type b vaccine HMO - health maintenance organization HRSA - Health Resources and Services Administration IAG - Interagency Vaccine Group IEM - Inborn errors of metabolism IgE - immunoglobulin E IL- 1 - interleukin 1 IL-6 - interleukin 6 IOM - Institute of Medicine IPV - inactivated polio vaccine KPMCP - Kaiser Permanente Medical Care Program LCHAD - long-chain 3 hydroxyacyl CoA dehydrogenase M CAD - medium- chain Acyl- CoA dehydrogenase NIAID - National Institute for Allergy and Infectious Disease at NIH NICHD - National Institute of Child Health and Human Development NIH - National Institutes of Health NIP - National Immunization Program NVPO - National Vaccine Program Office OPV - oral polio vaccine OR- odds ratio PCV - pneumococcus vaccine SIDS - sudden infant death syndrome SUDI - sudden unexpected death in infancy TNF - tumor necrosis factor TH2 -type 2 helper T-cells VAERS - Vaccine Adverse Events Reporting System VLCAD - very-long chain acyl-CoA dehydrogenase VSD - Vaccine Safety Datalink

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With current recommendations calling for infants to receive multiple doses of vaccines during their first year of life and with sudden infant death syndrome (SIDS) the most frequent cause of death during the postneonatal period, it is important to respond to concerns that vaccination might play a role in sudden unexpected infant death.

The committee reviewed epidemiologic evidence focusing on three outcomes: SIDS, all SUDI (sudden unexpected death in infancy), and neonatal death (infant death, whether sudden or not, during the first 4 weeks of life). Based on this review, the committee concluded that the evidence favors rejection of a causal relationship between some vaccines and SIDS; and that the evidence is inadequate to accept or reject a causal relationship between other vaccines and SIDS, SUDI, or neonatal death. The evidence regarding biological mechanisms is essentially theoretical, reflecting in large measure the lack of knowledge concerning the pathogenesis of SIDS.

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