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Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
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Appendix A
Workshop Agenda

ROLE OF ENVIRONMENTAL TOXICANTS IN PRETERM BIRTH

Sponsored by

Roundtable on Environmental Health Sciences, Research, and Medicine

National Academy of Sciences Auditorium

2101 Constitution Avenue, N.W., Washington, D.C.

October 2–3, 2001

Workshop Goals:

  • Summarize clinical and epidemiological aspects of prematurity.

  • Create understanding that exposures to environmental chemicals can alter gestation length.

  • Summarize cellular, molecular, and genetic aspects of control of preterm delivery.

  • Recognize that current in vivo and in vitro toxicological testing models are inadequately designed to capture the data that chemicals influence gestation length.

  • Given that preterm delivery is a substantial public health concern, develop toxicological approaches to improve understanding of chemical impacts on gestational length.

  • Use a multidisciplinary approach, including epidemiology, molecular, and so forth to better understand the mechanism underlying gestational length.

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×

TUESDAY, OCTOBER 2, 2001

8:30 a.m

Welcome and Opening Remarks

Paul G. Rogers, J.D.

Chair, Roundtable on Environmental Health Sciences, Research, and Medicine

Partner, Hogan and Hartson

8:40 a.m.

Remarks from the President of the March of Dimes

Jennifer Howse, Ph.D.

8:55 a.m.

Charge to Participants and Workshop Scope

Donald Mattison, M.D.

Member, Roundtable on Environmental Health Sciences, Research, and Medicine and Medical Director, March of Dimes

SESSION I: CLINICAL AND PUBLIC HEALTH ASPECTS OF PREMATURITY—CAUSES, INTERVENTIONS, AND CONSEQUENCES

Moderator:

Jeannette Rogowski, Ph.D.

Senior Economist

RAND Graduate School

9:30 a.m.

Causes and Mechanisms of Preterm Labor

James M. Roberts, M.D.

Senior Scientist and Director

Magee-Women’s Research Institute

10:00 a.m.

Clinical and Public Health Interventions—

Why Nothing Has Worked

Robert L. Goldenberg, M.D.

Charles E. Flowers, Professor

Department of Obstetrics and Gynecology, University of Alabama at Birmingham

10:30 a.m.

Long-Term Outcomes of Preterm Infants

Maureen Hack, M.D.

Professor of Pediatrics

Rainbow Babies and Children’s Hospital, University Hospitals of Cleveland

11:00 a.m.

Break

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×

SESSION II: ENVIRONMENTAL CAUSES OF PREMATURITY

Moderator:

E. Albert Reece, M.D.

Abraham Roth Professor and Chairman

Department of Obstetrics, Gynecology, and Reproductive Sciences, Temple University School of Medicine

11:30 a.m.

A Framework for Social and Cultural Determinants of Prematurity

Carol Hogue, Ph.D., M.P.H.

Terry Professor of Maternal and Child Health

Rollins School of Public Health, Emory University

12:00 p.m.

Toxic Social Environment: A Factor in Preterm Birth?

Janet W. Rich-Edwards, Sc.D.

Assistant Professor

Department of Ambulatory Care and Prevention, Harvard Medical School

12:30 p.m.

Lunch

SESSION III: ENVIRONMENTAL CAUSES OF PREMATURITY: ROLE OF ENVIRONMENTAL TOXICANTS

Moderator:

Donna S. Dizon-Townson, M.D.

Co-director

Perinatal Center, Utah Valley Regional Medical Center

1:30 p.m.

Epidemiologic Clues to the Study of the Environment and Preterm Birth

David Savitz, Ph.D.

Professor and Chair in Epidemiology

School of Public Health, University of North Carolina at Chapel Hill

2:00 p.m.

Exposures to Environmental Agents and Preterm Delivery

Matthew Longnecker, M.D.

Intramural Scientist

National Institute of Environmental Health Sciences (NIEHS)

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×

2:30 p.m.

Gene–Environment Interactions and Preterm Delivery

Xiaobin Wang, M.D., M.P.H., Sc.D.

Associate Professor

Boston University School of Medicine

3:00 p.m.

Break

SESSION IV: EXPERIMENTAL AND LABORATORY APPROACHES TO ANALYZING PREMATURITY

Moderator:

John R. G. Challis, Ph.D., D.Sc., FIBiol FRCOG FRSC

Scientific Director

Canadian Institutes of Health Research, Institute of Human Development, Child and Youth Health

3:30 p.m.

Current Approaches to Reproductive and Developmental

Toxicity Testing and Risk Assessment

Carole Kimmel, Ph.D.

Senior Scientist

Environmental Protection Agency

4:00 p.m.

Evaluating Chemical Agents for Potential Hazards in Reproduction

Jack B. Bishop, Ph.D.

Research Scientist, NIEHS

4:30 p.m.

Assessment and Relevance of Environmental Chemical Effects on Uterine Muscle

Rita Loch-Caruso, Ph.D.

Professor and Director of Toxicology

University of Michigan

5:00 p.m.

Reception

WEDNESDAY, OCTOBER 3, 2001

8:30 a.m.

Welcome Back

Lynn Goldman, M.D.

Vice-Chair, Roundtable on Environmental Health Sciences, Research, and Medicine

Professor, Johns Hopkins University, School of Public Health

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×

SESSION V: BIOLOGICAL PROCESSES THAT INFLUENCE PREMATURITY

Moderator:

Lynne Wilcox, M.D.

Director

Division of Reproductive Health, Centers for Disease Control and Prevention

8:45 a.m.

Species Differentiation and Animal Models of Parturition

Peter W. Nathanielsz, Ph.D.

James Law Professor of Reproductive Physiology

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University

9:15 a.m.

Function of Steroids in Parturition and Preterm Labor

William Gibb, Ph.D.

Professor

University of Ottawa, Canada

9:45 a.m.

Regulation and Assessment of Uterine Contractility and

Cervical Ripening During Pregnancy

Robert E. Garfield, Ph.D.

Professor and Director

Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch

10:15 a.m.

Molecular Mechanisms and Cellular Signaling Pathways Associated with Parturition

Barbara Sanborn, Ph.D.

Professor

Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School

10:45 a.m.

Break

11:00 a.m.

Models to Study the Actions of Uterine Lymphocytes

During Pregnancy

B. Anne Croy, Ph.D.

Professor

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×

11:30 a.m.

Role of Nitric Oxide in Uterine Activity and Preterm Parturition

Chandrasekhar Yallampalli, D.V.M., Ph.D.

Professor

Department of Obstetrics and Gynecology, University of Texas Medical Branch-Galveston

12:00 p.m.

Fetal Size and Preterm Birth

Stephen J. Lye, Ph.D.

Professor and Joint Head

Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Departments of Obstetrics and Gynecology and Physiology, University of Toronto

12:30 p.m.

Lunch

SESSION V: DISCUSSION

1:30 p.m.

Summation of the Workshop

Donald Mattison, M.D.

Member, Roundtable on Environmental Health Sciences, Research, and Medicine Medical Director, March of Dimes

2:00 p.m.

Panel Discussion

 

Woodie Kessel, M.D., M.P.H.

Assistant Surgeon General

U.S. Department of Health and Human Services

 

Mark Klebanoff, M.D.

Director

Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development

 

Allen J. Wilcox, M.D., Ph.D.

Chief of Epidemiology Branch

Environmental Diseases and Medicine Program, NIEHS, Division of Intramural Research

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×

 

Daniel Krewski, Ph.D.

Professor and Director

R. Samuel McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Canada

 

Carole Kimmel, Ph.D.

Senior Scientist

National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency (EPA)

 

Charles J. Lockwood, M.D.

Professor and Chairman

Department of Obstetrics and Gynecology, New York University School of Medicine

 

Karla H. Damus, Ph.D., R.N.

Director, Community Programs

Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein School of Medicine

 

Fernando Guerra, M.D.

Director of Health

San Antonio Metropolitan Health District, Texas

 

Catherine Spong, M.D.

Chief

Pregnancy and Perinatology Branch, NICHD, National Institutes of Health

4:30 p.m.

Adjournment

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
Page 113
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
Page 114
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
Page 115
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
Page 116
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
Page 117
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
Page 118
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2003. The Role of Environmental Hazards in Premature Birth: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10842.
×
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Each year in the United States approximately 440,000 babies are born premature. These infants are at greater risk of death, and are more likely to suffer lifelong medical complications than full-term infants. Clinicians and researchers have made vast improvements in treating preterm birth; however, little success has been attained in understanding and preventing preterm birth. Understanding the complexity of interactions underlying preterm birth will be needed if further gains in outcomes are expected.

The Institute of Medicine’s Roundtable on Environmental Health Sciences, Research, and Medicine sponsored a workshop to understand the biological mechanism of normal labor and delivery, and how environmental influences, as broadly defined, can interact with the processes of normal pregnancy to result in preterm birth. This report is a summary of the main themes presented by the speakers and participants.

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