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Appendix 1 FORMAT FOR SMAC DOCUMENTS Background Information Physical and Chemical Properties Occurrence and Use Summary of Toxicity Information Effects on Humans Effects on Animals Acute, Subacute, and Chronic Exposures Mutagenicity, Teratogenicity, and Carcinogenicity Pharmacokinetics Absorption and Distribution Metabolism and Excretion Inhalation Exposure Levels (from other sources, such as TLVs from ACGIH and PELs from OSHA standards) Committee Recommendations (emergency exposure guidance levels: current and prior COT recommendations and rationale for new numbers) Recommendations for Future Research (when applicable) Tables References (and cutoff date for published papers) 709
108 GUIDELINES FOR DEVELOPING SMACS Travis, C.C., and R.K. White. 1988. Interspecific scaling of toxicity data. Risk Anal. 8:119-125. Wallace, L.A. 1987. The Total Exposure Assessment Methodolgoy (TEAM) Study: Summary and Analysis, Vol. I. EPA 600/6-87/ 002a. Washington, D.C.: U.S. Environmental Protection Agency. Waxweiler, R.J., W. Stringer, J.K. Wagoner, J. Jones, H. Falk, and C. Carter. 1976. Neoplastic risk among workers exposed to vinyl chloride. Ann. N.Y. Acad. Sci. 271:40-48. Weinberg, R.A. 1991. Tumor suppressor genes. Science 254:1138- 1146. Whedon, G.D. 1984. Disuse osteoporosis: Physiological aspects. Calcif. Tissue Int. 36:S146-S150. Whedon, G.D., L. Lutwak, J. Reid, P. Rambaut, M. Whittle, M. Smith, and C. Leach. 1974. Mineral and nitrogen metabolic studies on Skylab orbital space flights. Trans. Assoc. Am. Physicians 87:95-110. Whittemore, A., and J. Keller. 1978. Quantitative theories of car- cinogenesis. SIAM Rev. 20:1-30. Whittemore, A.S., and A. McMillan. 1983. Lung cancer mortality among U.S. uranium miners: A reappraisal. J. Natl. Cancer Inst. 71:489-499. Wyrobek, A.J., and W.R. Bruce. 1978. The induction of sperm-shape abnormalities in mice and humans. Pp. 257-285 in Chemical Muta- gens: Principles and Methods for Their Detection, Vol. 5, A. Hollaender and F.J. de Serres, eds. New York: Plenum. Wyrobek, A.J., M. Currie, J.L. Stilwell, R. Balhorn, and L.H. Stanker. 1990. Detecting specific-locus mutations in human sperm. Pp. 93-109 in Biology of Mammalian Germ Cell Mutagenesis. Banbury Report 34, J.W. Allen, B.A. Bridges, M.F. Lyon, M.J. Moses, and L.B. Russell, eds. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press.
