National Academies Press: OpenBook
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

Soliciting Stakeholder Input for a
Revision of Biosafety in Microbiological
and Biomedical Laboratories (BMBL)

Proceedings of a Workshop

Camilla Y. Ables, Rapporteur

Board on Agriculture and Natural Resources

Division on Earth and Life Studies

images

THE NATIONAL ACADEMIES PRESS
Washington, DC
www.nap.edu

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001

This activity was supported by Grant No. HHSN263201200074I from HHS and NIH. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

Digital Object Identifier: 10.17226/23585

Copyright 2016 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America

Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

Image

The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

The National Academy of Engineering was established in 1964 under the charter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineering. Dr. C. D. Mote, Jr., is president.

The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president.

The three Academies work together as the National Academies of Sciences, Engineering, and Medicine to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine.

Learn more about the National Academies of Sciences, Engineering, and Medicine at www.national-academies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

Image

Reports document the evidence-based consensus of an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and committee deliberations. Reports are peer reviewed and are approved by the National Academies of Sciences, Engineering, and Medicine.

Proceedings chronicle the presentations and discussions at a workshop, symposium, or other convening event. The statements and opinions contained in proceedings are those of the participants and are not necessarily endorsed by other participants, the planning committee, or the National Academies of Sciences, Engineering, and Medicine.

For information about other products and activities of the Academies, please visit nationalacademies.org/whatwedo.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

COMMITTEE ON SOLICITING STAKEHOLDER INPUT FOR A REVISION OF “BIOSAFETY IN MICROBIOLOGICAL AND BIOMEDICAL LABORATORIES”: A WORKSHOP AND VIRTUAL TOWN HALL1

Members

ROBERT ELLIS (Chair), Colorado State University

DEBRA HUNT, Duke University

TOM KSIAZEK, University of Texas Medical Branch

Study Staff

CAMILLA YANDOC ABLES, Study Director

JENNA BRISCOE, Senior Program Assistant

ROBIN A. SCHOEN, Director, Board on Agriculture and Natural Resources

___________________

1The committee members were not involved in the writing of the proceedings of the workshop.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

BOARD ON AGRICULTURE AND NATURAL RESOURCES

Members

CHARLES W. RICE (Chair), Kansas State University, Manhattan

HAROLD L. BERGMAN, University of Wyoming, Laramie

SUSAN CAPALBO, Oregon State University, Corvallis

GAIL CZARNECKI-MAULDEN, Nestle Purina PetCare, St. Louis, Missouri

RICHARD A. DIXON, NAS,1 University of North Texas, Denton

GEBISA EJETA, Purdue University, West Lafayette, Indiana

ROBERT B. GOLDBERG, NAS,1 University of California, Los Angeles

FRED GOULD, NAS,1 North Carolina State University, Raleigh

GENE HUGOSON, University of Minnesota, St. Paul

JAMES W. JONES, NAE,2 University of Florida, Gainesville

STEPHEN S. KELLEY, North Carolina State University, Raleigh

JIM E. RIVIERE, NAM,3 Kansas State University, Manhattan

Staff

ROBIN A. SCHOEN, Director

CAMILLA YANDOC ABLES, Program Officer

JENNA BRISCOE, Senior Program Assistant

KARA N. LANEY, Program Officer

PEGGY TSAI YIH, Senior Program Officer

___________________

1National Academy of Sciences.

2National Academy of Engineering.

3National Academy of Medicine.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

ACKNOWLEDGEMENT OF REVIEWERS

This proceedings of a workshop has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published proceedings as sound as possible and to ensure that the proceedings meets institutional standards for objectivity, evidence, and responsiveness to the study charge. We wish to thank the following individuals for their review of this proceedings:

Kenneth Berns, University of Florida (emeritus)

Sherry Bohn, University of Maryland

Maureen Ellis, International Federation of Biosafety Associations

Robert Ellis, Colorado State University

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse, nor did they see, the final draft of the proceedings before its release. The review of the proceedings was overseen by Ron Atlas of the University of Louisville, he was responsible for making certain that an independent examination of the proceedings was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of the proceedings of a workshop rests entirely with the author and the National Academies of Sciences, Engineering, and Medicine.

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

This page intentionally left blank.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

CONTENTS

INTRODUCTION

WORKSHOP DISCUSSION

Soliciting Stakeholder Input – Opening Remarks by NIH and CDC

The BMBL as a Guidance Document

Q&A Session with NIH and CDC

General Comments on the BMBL

Comments on BMBL Section I – Introduction

Comments on BMBL Section II – Biological Risk Assessment

Comments on BMBL Section III – Principles of Biosafety

Comments on BMBL Section IV – BSL Criteria

Comments on BMBL Section V – Vertebrate Animal BSL Criteria

Comments on BMBL Section VI – Principles of Laboratory Biosecurity

Comments on BMBL Section VII – Occupational Health and Immunoprophylaxis

Comments on BMBL Section VIII – Agent Summary Statements

Comments on BMBL Appendix A – Primary Containment for Biohazards

Comments on BMBL Appendix B – Decontamination and Disinfection

Comments on BMBL Appendix C – Transportation of Infectious Substances

Comments on BMBL Appendix D – Agricultural Pathogen Biosafety

Comments on BMBL Appendix E – Arthropod Containment Guidelines

Comments on BMBL Appendix F – Select Agents and Toxins

Comments on BMBL Appendix G – Integrated Pest Management

Comments on BMBL Appendix H – Working with Human, NHP and Other Mammalian Cells and Tissues

Comments on BMBL Appendix I – Toxins of Biological Origin

Comments on BMBL Appendix J – NIH Oversight of Research Involving Recombinant Biosafety Issues

Comments on BMBL Appendix K – Resources

Comments on BMBL Appendix L – Acronyms

Revising the BMBL: Final Thoughts

Closing Remarks

APPENDIXES

A BIOGRAPHICAL SKETCHES OF STEERING COMMITTEE

B WORKSHOP AGENDA

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×

This page intentionally left blank.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R1
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R2
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R3
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R4
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R5
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R6
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R7
Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R8
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R9
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23585.
×
Page R10
Next: INTRODUCTION »
Soliciting Stakeholder Input for a Revision of Biosafety in Microbiological and Biomedical Laboratories (BMBL): Proceedings of a Workshop Get This Book
×
Buy Ebook | $9.99
MyNAP members save 10% online.
Login or Register to save!
Download Free PDF

Since its publication by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) in 1984, Biosafety in Microbiological and Biomedical Laboratories (BMBL) has become the cornerstone of the practice of biosafety in the United States and in many countries around the world. The BMBL has been revised periodically over the past three decades to refine the guidance it provides based on new knowledge and experiences—allowing it to remain a relevant, valuable, and authoritative reference for the microbiological and biomedical community.

Seven years after the release of the BMBL 5th Edition, NIH and CDC are considering a revision based on the comments of a broader set of stakeholders. At the request of NIH, the National Academies of Sciences, Engineering and Medicine conducted a virtual town hall meeting from 4 April to 20 May 2016 to allow BMBL users to share their thoughts on the BMBL in general and its individual sections and appendices. Specifically, users were asked to indicate what information they think should be added, revised, or deleted. Major themes from the virtual town hall meeting were further discussed in a workshop held on 12 May 2016 in Washington, DC. This document encapsulates the discussion of the major comments on the BMBL that were posted on the virtual town hall prior to 12 May 2016 and the various BMBL comments and issues related to biosafety that were raised during the workshop by participants who attended the meeting in Washington DC and those who listened to the live webcast.

  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text.

    « Back Next »
  6. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  7. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  8. ×

    View our suggested citation for this chapter.

    « Back Next »
  9. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!