Forum on Drug Discovery, Development, and Translation: Annual Report 2009 (2010)

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Promoting global leadership in drug development Promoting global leadership in drug development and translation The Forum’s initiative on multidrug-resistant tuberculosis (MDR TB) includes a series of workshops quickly gain- ing international attention. The first workshops—held in the United States—presented new data on the mag- nitude of the MDR TB problem and the challenges to addressing the rapid spread of drug-resistant tuberculosis. These initial meetings led to the development of workshops to take place in the four highest burden countries— South Africa, Russia, China, and India. A workshop to be held in Moscow in May 2010 became the subject of negotiations for a Memorandum of Understanding between the Academies, NIH, and the Russian Academy of Sciences. The agreement was acknowledged by President Obama and Secretary Clinton during the President’s visit to Moscow and led to collaboration between IOM and NIAID to develop coordinated MDR TB meetings in both Russia and South Africa in 2010. February – Capitol Hill Briefing on April – Workshop on Streamlining Clinical Multidrug-Resistant Tuberculosis Trial and Material Transfer Negotiations 2009 March – FDA Community Update on Personalized  Medicine and the Genetic Basis of Adverse Events 

The Global Threat of Multidrug-Resistant Promoting global leadership in drug development Tuberculosis (MDR TB) Building on its November 2008 workshop on multidrug-resistant tuberculosis, Addressing the Threat of Drug-Resistant Tuberculosis: A Realistic Assessment of the Challenges, the Forum met on Capitol Hill in February 2009 to update members of Congress, their staffs, and poli- cymakers on the global challenges of MDR TB. The meeting addressed growing problems in transmission and infection control, diagnosis, Paul Zintl, Partners-in-Health; Anthony Fauci, NIAID, NIH; drug supply and quality, treatment, and the lack of new drug thera- Ken Castro, CDC pies for fighting TB. Speakers addressed existing efforts identified leadership funding gaps, and discussed possible roles for the U.S. government. A published summary of the first workshop in November 2008, as well as presentations from both meetings, are now available on the Forum website. A series of follow-on workshops in the four most high-burden coun- tries—South Africa, Russia, India, and China—are currently in development. Michael Ugrumov, Russian Academy of Sciences, and Forum Co-chair, Gail Cassell Paul Farmer, Partners in Health September – FDA Community Update on Post-Market Drug Safety October – Workshop on Transforming Clinical Research