NATIONAL ACADEMY OF SCIENCES
Colloquium Series
In 1991, the National Academy of Sciences inaugurated a series of scientific colloquia, five or six of which are scheduled each year under the guidance of the NAS Council’s Committee on Scientific Programs. Each colloquium addresses a scientific topic of broad and topical interest, cutting across two or more of the traditional disciplines. Typically two days long, colloquia are international in scope and bring together leading scientists in the field. Papers from colloquia are published in Proceedings of the National Academy of Sciences (PNAS).
COMPLETED NAS COLLOQUIA
(1991 TO PRESENT)
Industrial Ecology
May 20–21, 1991; Washington, D.C.
Organizer: C.Kumar N.Patel
Proceedings: February 4, 1992
Images of Science: Science of Images
January 13–14, 1992; Washington, D.C.
Organizer: Albert Crewe
Proceedings: November 3, 1993
Physical Cosmology
March 27–29, 1992; Irvine, California
Organizer: David Schramm
Proceedings: June 3, 1993
Molecular Recognition
September 10–11, 1992; Washington, D.C.
Organizer: Ronald Breslow
Proceedings: February 16, 1993
Human-Machine Communication by Voice
February 8–9, 1993: Irvine, California
Organizer: Lawrence Rabiner
Proceedings: October 24, 1995
Changing Human Ecology and Behavior: Effects on Infectious Diseases
September 27–28, 1993; Washington, D.C.
Organizer: Bernard Roizman
Proceedings: March 29, 1994
The Tempo and Mode of Evolution
January 27–29, 1994; Irvine, California
Organizers: Francisco Ayala, Walter Fitch
Proceedings: July 19, 1994
Chemical Ecology: The Chemistry of Biotic Interaction
March 25–26, 1994; Washington, D.C.
Organizers: Thomas Eisner, Jerrold Meinwald
Proceedings: January 3, 1995
Physics: The Opening to Complexity
June 25–27, 1994; Irvine, California
Organizer: Philip Anderson
Proceedings: July 18, 1995
Self Defense by Plants: Induction and Signaling Pathways
September 15–17, 1994; Irvine, California
Organizers: André Jagendorf, Clarence Ryan
Proceedings: May 9, 1995
Earthquake Prediction
February 10–11, 1995; Irvine, California
Organizer: Leon Knopoff
Proceedings: April 30, 1996
Quasars and Active Galaxies: High Resolution Radio Imaging
March 24–25, 1995; Irvine, California
Organizers: Marshall Cohen, Kenneth Kellerman
Proceedings: December 5, 1995
Vision: From Photon to Perception
May 21–22, 1995; Irvine, California
Organizers: John Dowling, Lubert Stryer, and Torsten Wiesel
Proceedings: January 23, 1996
Science, Technology, and the Economy
October 20–22, 1995; Irvine, California
Organizers: James Heckman, Ariel Pakes, and Kenneth Sokoloff
Proceedings: November 12, 1996
Developmental Biology of Transcription Control
October 25–28, 1995; Irvine, California
Organizers: Roy Britten, Eric Davidson, and Gary Felsenfeld
Proceedings: September 3, 1996
Carbon Dioxide and Climate Change
November 13–15, 1995; Irvine, California
Organizer: Charles Keeling
Proceedings: August 5, 1997
Memory: Recording Experience in Cells and Circuits
February 17–20, 1996; Irvine, California
Organizer: Patricia Goldman-Rakic
Proceedings: November 26, 1996
COMPLETED NAS COLLOQUIA
Elliptic Curves and Modular Forms
March 15–17, 1996; Washington, D.C.
Organizers: Barry Mazur, Karl Rubin
Proceedings: October 14, 1997
Symmetries Throughout the Sciences
May 10–12, 1996; Irvine, California
Organizer: Ernest Henley
Proceedings: December 15, 1996
Genetic Engineering of Viruses and Viral Vectors
June 9–11, 1996; Irvine, California
Organizers: Peter Palese, Bernard Roizman
Proceedings: October 15, 1996
Genetics and the Origin of Species
January 30-February 1, 1997; Irvine, California
Organizers: Francisco Ayala, Walter Fitch
Proceedings: July 22, 1997
The Age of the Universe: Dark Matter and Structure Formation
March 21–23, 1997; Irvine, California
Organizers: David Schramm, P.J.E.Peebles
Proceedings: January 6, 1998
Neuroimaging and Human Brain Function
May 29–31, 1997; Irvine, California
Organizers: Michael Posner, Marcus Raichle
Proceedings: February 3, 1998
Protecting Our Food Supply: The Value of Plant Genome Initiatives
June 2–4, 1997; Irvine, California
Organizers: Michael Freeling, Ronald Phillips, John Axtell
Proceedings: March 5, 1998
Computational Biomolecular Science
September 11–14, 1997; Irvine, California
Organizers: Peter G.Wolynes, Russell Doolittle, J.A.McCammon
Proceedings: May 26, 1998
A Library Approach to Chemistry
October 19–21, 1997; Irvine, California
Organizer: Peter Schultz, Jonathan Ellman
PROGRAM
Computational Biomolecular Science
Thursday, September 11, 1997 Registration and Welcome Reception |
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Friday, September 12, 1997 |
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Session I |
8:45 AM-12:30 PM Introduction, Peter Wolynes. Measuring genome evolution. Peer Bork (EMBL, Heidelberg). Determining biological function from sequence: Building highly specific sequence motifs for genome analysis. Douglas Brutlag (Stanford). Experimental studies of protein folding dynamics. William Eaton (NIH). Coupling the folding of homologous proteins. Ron Elber (Hebrew University). |
Chair, Russell Doolittle |
Session II |
2:00 PM-5:30 PM Photoactive yellow protein: Prototype for the PAS domains of sensors and clocks. Elizabeth Getzoff (Scripps Research Institute). Inhomogeneities in genomic sequence composition. Philip Green (Univ. Washington). New refinement methods for NOE-distance based NMR structure. Angela Gronenborn (NIH). Estimation of evolutionary distances between DNA sequences. Wen-Hsiung Li (Univ. Texas, Houston). Comments by Roy Britten After-dinner Lecture. From slide rule to super computer. Hans Frauenfelder (Los Alamos). |
Chair, Andrew McCammon |
Saturday, September 13, 1997 |
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Session III |
9:00 AM-12:30 PM Comparing sequence comparison with structure comparison. Michael Levitt (Stanford). Structural classification of proteins and its evolutionary implications. Alexey Murzin (MRC, Cambridge). Exploring the protein folding funnel landscape-connection to fast folding experiments. Jose Onuchic (UCSD). Bridged bimetallic enzymes: A challenge for computational chemistry. Gregory Petsko (Brandeis). |
Chair, Andrew McCammon |
Session IV |
2:00 PM-5:30 PM Sequence determinants of protein folding and stability. Robert Sauer (MIT). The evolution of efficient light harvesting in photosynthesis-one goal, many solutions. Klaus Schulten (Illinois). Electrostatic steering and ionic tethering in simulations of protein-ligand interactions. Rebecca Wade (EMBL, Heidelberg). Computer simulation of enzymatic reactions and other biological process; finding out what was optimized by evolution. Arieh Warshel (USC). After-dinner Lecture. Applications of computers in structural biology. Harold Scheraga (Cornell). |
Chair, Peter Wolynes |
LIST OF ATTENDEES
Computational Biomolecular Science
Robert K.Adair, Yale University
Paul A.Bash, Argone National Laboratory
R.L.Bernstein, San Francisco State University
Paul Beroza, CombiChem Inc.
Peer Bork, European Molecular Biology Laboratory
David A.Brant, University of California
Roy J.Britten, California Institute of Technology
Thomas C.Bruice, University of California, Santa Barbara
Douglas Brutlag, Stanford University Medical School
Aloke Chatterjee. Lawrence Berkeley National Laboratory
Jiangang Chen, University of California, Los Angeles
Margaret S.Cheung, University of California, San Diego
Julian D.Cole, Rensselaer Polytechnic Institute
Kumari Devulapalle, University of Southern California, School of Dentistry
Russel F.Doolittle, University of California, San Diego
William Eaton, National Institutes of Health Ron Elber, Hebrew University
Adrien Elcock, University of California, San Diego
Hans Frauenfelder, Los Alamos National Laboratory
Anthony Gamst, University of California, San Diego
Robert Gerber, University of California, Irvine
Elizabeth D.Getzoff, Scripps Research Institute
Raveh Gill-More, Compugen Ltd.
Adam Godzik, The Scripps Research Institute
Jill E.Gready, Australian National University
Phillip Green, University of Washington
Angela M.Gronenborn, National Institutes of Health
William Grundy, University of California. San Diego
Volkhard Helms, University of California San Diego
Dennis Kibler, University of California, Irvine
Robert Konecny, The Scripps Research Institute
Kristin Korethe, Smith Kline Beecham
Leslie A.Kuhn, Michigan State University
Donald Kyle, Scios Inc.
Peter W.Langhoff, San Diego Supercomputer Center
Michael Levitt, Stanford University, School of Medicine
Jian Li, The Scripps Research Institute
Wen-Hsiung Li, University of Texas
E.N.Lightfoot, University of Wisconsin
Jennifer H.Y.Liu, University of California
Hartmut Luecke, University of California, Irvine
Jia Luo, University of California, Santa Barbara
Zaida Luthey-Schultem, University of Ilinois
Jeffry D.Madura, University of South Alabama
J.Andrew McCammon, University of California, San Diego
Gregory Mooser, University of Southern California, School of Dentistry
Victor Munoz, National Institutes of Health
Alexey G.Murzin, Centre for Protein Engineering
Craig Nevill-Manning, Stanford University
Louis Noodleman, The Scripps Research Institute
Hugh Nymeyer, University of California, San Diego
Jose N.Onuchic, University of California, San Diego
Jean-Luc Pellequer, The Scripps Research Institute
Gregory A.Petsko, Brandeis University
Mike Potter, University of California, San Diego
Vijay S.Reddy, The Scripps Research Institute
Carolina M.Reyes, University of California, San Francisco
Roy Riblet, Medical Biology Institute
Andrey Rzhetsky, Columbia University
Suzanne B.Sandmeyer, University of California, Irvine
Robert Sauer, Massachusetts Institute of Technology
Harold Scheraga, Cornell University
Rebecca K.Schmidt, Australian National University
Klaus Schulten, University of Illinois
Soheil Shams, BioDiscovery
Sylvia Spengler, Lawrence Berkeley National Laboratory
Tim Springer, Center for Blood Research
T.P.Straatsma, Pacific Northwest National Laboratory
Ivan Suthsland, Sun Microsystems Laboratories
Mounir Tarek, National Institute of Standards and Technology
Douglas Tobias, University of California, Irvine
Chandra S.Verma, University of York
Rebecca Wade, European Molecular Biology Laboratory
Frederic Y.M.Wan, University of California, Irvine
Arieh Warshel, University of Southern California
Stephen H.White, University of California, Irvine
Peter Wolynes, National Institutes of Health
Willy Wriggers, University of Illinois at Urbana-Champaign
William V.Wright University of North Carolina
Thomas Wu, Stanford University
Qiang Zhenq, Scios Inc.
PROCEEDINGS
OF THE
NATIONAL ACADEMY OF SCIENCES
OF THE UNITED STATES OF AMERICA
Table of Contents
Papers from a National Academy of Sciences Colloquium on Computational Biomolecular Science