Multiple Sclerosis Current Status and Strategies for the Future (2001) / Chapter Skim
Currently Skimming:
Appendix E: Drugs Used in the Treatment of MS
Appendix E: Drugs Used in the Treatment of MS
Pages 387-400
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From page 387... ...
Appendix E Dams Used ~ me Deemed ~ AS ~ 0~ go/
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From page 390... ...
and Europe As above Total lymphoid irradiation Off label use in the U.S. and Europe As above Paclitaxel Phase II Clinical Trials As above 2-Chlorodeoxyadenosine Phase III Clinical Trials As above Mitoxantrone Phase III Clinical Trials As above IMMUNOMODULATION Therapeutic Medication Status as Putative Mechanisms Strategy Options of 1999 Of Action 1)
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and Europe Phase II Phase I 5) Alter the balance Antibodies to TNFa, Phase I/II of pro-inflammatory IL- 1 (Thl)
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Eliprodil Pirfenidone Testing discontinued; phase III trial revealed an increase in heart attacks associated with this drug Phase I Preclinical testing Phase I Blocks Thl differentiation and effecter function, inhibits IFNg production Inhibits TNF production Prevent neuronal death Prevent neuronal death Prevents gliosis, blocks TNF synthesis continued
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From page 393... ...
and Europe, remyelination Phase III Oli go den droc yte grafts Preclinical testing Promote remyelination Eliprodil Preclinical testing Promote remyelination
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394 APPENDIX E o to to to Cut o z o 2 A o to o En o z o C)
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396 z o o to to Cal En o z o > z o to o En In a a z a APPENDIX E C)
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398 APPENDIX E z ~ 3 ~ ~ ~ Q ° ~ ~ ~ o ~ ~ ca c)
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From page 400... ...
400 APPENDIX E Drugs Usecl to Treat Various Symptoms: Overview Bladder Control Capsaicin Desmopressin Detrol Dicyclomine hydrochloride Hyoscyamine .
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