Skip to main content

Interim Report #4 on Spacecraft Water Exposure Guidelines (2000) / Chapter Skim
Currently Skimming:

EXECUTIVE SUMMARY
Pages 1-3

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 1...
... To ensure that the SWEGs are developed in accordance with the guidelines, NASA requested that this National Research Council subcommittee independently review the draft SWEGs documents. In performing the review, the subcommittee reviews the documents as many times as necessary until it is satisfied that the SWEGs are scientifically justified.
Read the entire page →
From page 2...
... Zinc and Its Salts • NASA needs to re-evaluate and make adjustments to several of its AC calculations for zinc. NASA should -- reconsider its decision to use an uncertainty factor lower than 10 to extrapolate from a LOAEL to a NOAEL when the selected end point is considered to be an insignificant health effect; and -- analyze the relevance and significance of the finding of decreased superoxide dismutase in humans exposed to zinc; the available data can be handled in a variety of ways to determine an AC on the basis of that end point, and NASA should evaluate all of the possible options before making a decision.
Read the entire page →
From page 3...
... Di-n-butyl Phthalate (DBP) • The subcommittee concludes that NASA's SWEGs document on DBP is ready to be finalized once NASA has corrected the AC calculations that used a BMD.
Read the entire page →

Key Terms

  • water contaminants
  • swegs documents
  • bmd approach
  • butyl phthalate
  • crew performance

  • individual water
  • eight swegs
  • draft swegs
  • closed spacecraft
  • selected water

  • dosing methods
  • manganese following
  • key toxicity
  • ranking contaminants
  • nasa requested

  • continuous exposure
  • guidance document
  • subcommittee concludes
  • dehp using
  • rats exposed

  • sensitization potential
  • review priority
  • data reported
  • cell vacuolization
  • prevent irreversible

  • documents drafted
  • irreversible harm
  • conditions lasting
  • nephrotoxicity data
  • toxicity studies


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.