Biographical Memoirs Volume 79 (2001) / Chapter Skim
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Hans Joachim Muller-Eberhard
Hans Joachim Muller-Eberhard
Pages 246-261
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Hans's class at school was sent to an anti-aircraft battery on the outskirts of Magcleburg where they replacer! regular army units.
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While in Altenau, he also began studying with increasing pleasure textbooks of chemistry en cl physics. He augmented his meager financial resources by climbing fir trees to harvest the cones, a very hazardous occupation since the best semis were frequently at the top of trees 10 to 15 meters tall.
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the carbohydrate component of gamma globulin, he cliscoverecl that the carbohydrate content of gamma globulin was entirely represented by the 19S component. This observation clemolishec!
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He cleciclecl to use this method to compare the pattern obtained of untreated human serum with that of serum incubated with an immune precipitate to activate complement. Careful inspection reproducibly revealed an electrophoretic shift of a minor component within the ,8-gIobulin region of the treater!
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The first demonstration en cl purification of a specific protein in the complement system, this was a critical event, for it was the beginning of a series of molecular identifications of the proteins of the complement system. As Maclyn McCarty notecl in 1971 on presenting him the Helen Hay Whitney Duckett Award, "You have liftecl complement out of its primorclial slime." Working with C3, Eberharcl iclentifiecl an active enzyme called C3B convertase, which converts C3 to C3A.
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His elegant Harvey Lecture in 1970 was one of the best en cl clearest summaries of the biology of complement at that time. His review in Annual Reviews of Biochemistry on the complement system also revealecl the rigorous clarity of thought that was an essential feature of Eberharcl's scientific papers, both oral en c!
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the German government, which proviclecl generously for the institute. The Fecleral Ministry of Research en cl Technology provided ample sums allowing for 30 "hard" money positions for scientists.
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It is worth emphasizing that he was always concerned with human disease and, although not primarily a physician, his interest in the welfare of the patients was a major concern. In 1990 the Bernhard Nocht Institute observed its ninetieth anniversary.
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Somewhat surprisingly, Eberharcl proved to be an effortless but highly successful funciraiser within the Texan business woricI. It was greatly to the clisacivantage of the institute en cl to the misfortune of his many friends that carcinoma of the prostate was cliagnosec!
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His loyalty followed the acivice of Polonius, "The friends thou hast, en cl their adoption tried, grapple them unto thy soul with hoops of steel." He clic! incleecI.
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Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.
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The membrane attack mechanism of complement: Reversible interactions among the five native components in free solution.
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Kolb. The C5b-9 complex: Subunit composition of the classical and alternative pathway generated complex.
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Tannich. Amoebapores: A family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: Isolation, primary structure, and pore formation in bacterial cytoplasmic membranes.
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