Veterans and Agent Orange Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans (2002) / Chapter Skim
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the increased risk of the disease associated with exposure to herbicides during Vietnam service; (3) whether there is a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease.
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For female veterans, it could have occurred during early pregnancy. Two other analyses not previously reviewed in a Veterans and Agent Orange series report were also evaluated by the committee: a paper on cancer morbidity in the children of agricultural workers in Norway (Kristensen et al., 1996)
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Biologic Plausibility Studies reviewed in earlier Veterans and Agent Orange series reports suggest that the reproductive systems of adult male laboratory animals are relatively insensitive to TCDD. Effects on testes and accessory organ weights, testicular morphology, spermatogenesis, and fertility were observed in many species, including rats, mice, guinea pigs, marmosets, monkeys, and chickens, but generally occurred only at doses that caused overt toxicity.
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