Biographical Memoirs Volume 81 (2002) / Chapter Skim
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Karl August Folkers
Karl August Folkers
Pages 100-115
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From page 101... ...
His work on the structure, synthesis, en cl meclical use of naturally occurring, biologically active compounds, such as alkaloicis, antibiotics, B-vitamins, hormones, en cl coenzymes, has hacl lasting impact. He playocl unique roles in the structural determination en c!
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... student at the University ot Illinois his undergraduate experience included working in food service as well as the chemistry library and pursuing a senior thesis directed by Carl ("Speed")
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total synthesis of pantothenic acid by completing the structure of the lactone moiety. Karl received the American Chemical Society Awarcl for meritorious work in pure chemistry in 1941 baser!
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As a consequence Karl arranged for Shorb to test a group of samples that included a clinically active liver extract preparation passer! through alumina.
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The relationship of this factor to the biosynthesis of cholesterol ultimately macle possible direct biochemical approaches to the control of cholesterol biosynthesis associated with heart disease. For his achievements he received the Scientific Awarcl of the Board of Directors of Merck in 1951.
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For over two decades Bowers and Folkers continued extensive research on hypothalamic hormones en cl their anaTogs. The luteinizing hormone releasing hormone (LHRH)
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Such biochemical evidence for the cause of disease was a driving force in the research career of Karl Folkers. Folkers' search for meclical applications for coenzyme Q resultecl in the observation that inacloquate biosynthesis may occur in tissues of patients with various chronic clisorclers.
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From page 108... ...
He actively directed his Institute for Biomedical Research from his Lake Sunapee summer home over the last two years of his life with the aid of his colleague Richard Willis. He remained actively involved in research up through his final day, December 9, 1997.
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, on the Drug Development Committee of the National Cancer Institute (1974-78) , on the Board of Editors for several scientific journals, in various positions in the American Chemical Society, en cl as a member of various advisory committees for the National Academy of Sciences en cl for many American en c!
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, as well as insight from conversations with Richard Willis. (This memoir was edited by Kathleen Shive Matthews and Karen Shive Browning following the untimely death of William Shive on October 2, 2001.)
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From page 111... ...
VIII. The total synthesis of pure pantothenic acid.
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112 B I O G RA P H I C A L 1948 EMOIRS With F
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Antide and related antagonists of luteinizing hormone release with long action and oral activity.
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From page 114... ...
114 BIOGRAPHICAL MEMOIRS 1990 With P Langsjoen, R
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