Toxicologic Assessment of Jet-Propulsion Fuel 8 (2003) / Chapter Skim
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5 Effects of Jet-Propulsion Fuel 8 on the Nervous System
5 Effects of Jet-Propulsion Fuel 8 on the Nervous System
Pages 56-70
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From page 56... ...
The subcommittee used the available information on JP-8 to assess the potential for toxic effects ofJP-8 on the nervous system in humane. SUMMARY OF STUDIES DISCUSSED IN THE 1996 NATIONAL RESEARCH COUNCIL REPORT The National Research Council Subcommittee on Permissible Exposure Levels for Military Fuels reviewed studies on the potential toxic effects of JP5, JP-8, and diesel fuel marine (D FM)
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From page 57... ...
The effectiveness of vapors as CNS depressants depends principally upon the volatility of their component hydrocarbons. The Subcommittee on Permissible Exposure Levels for Military Fuels found that data on potential nervous system effects of jet fuels are sparse.
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58 cn cot ._ cn coo cat us ¢ cn cn v: cat cn o cat o cn o , ~ ~ ~ ~ e , A, ~ a, ~ .
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From page 61... ...
It is not known whether exposure to such chemicals at the concentrations found inJP8 will cause adverse neurologic effects and whether their presence in the mixture produces additive, synergistic, or antagonistic effects. EFFECTS OF EXPOSURE TO JP-8 IN EXPERIMENTAL ANIMALS This section describes experimental-animal studies that have assessed the neurotoxic potential ofJP-8 and related fuels.
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The neurologic tests included the acousticstartle response, prepulse inhibition of the acoustic-startle response, appetitive-reinforcer approach sensitization, forelimb grip strength, locomotor activity, tail-flick response, conspecific approach, passive avoidance, Porsalt forced-swim test, and Morris water maze. After the neurobehavioral testing, concentrations of norepinephrine, dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in several regions of the brain and in blood were analyzed.
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. Neurobehavioral measures assessed were forelimb grip strength, photosensitivity, appetitive-reinforcer approach sensitization, total locomotor activity, acoustic startle and prepulse inhibition, tail-flick response, and treadmill physical fatigue.
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CONCLUSIONS AND RECOMMENDATIONS . To evaluate the potential forJP-8 to cause adverse neurologic effects, the subcommittee reviewed the available data on the neurotoxicity ofJP-8, related jet fuels, and kerosene in humans and experimental animals.
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The subcommittee also recommends studies in experimental animals to examine the potential neurotoxic effects ofJP-8. Specifically, the subcommittee recommends that neurologic (histologic, physiologic, and behavioral)
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2001. Eyeblink conditioning response test used to assess performance in ~P-8 exposed air force personnel.
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From page 70... ...
1996. Permissible Exposure Levels for Selected Military Fuel Vapors.
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