Intentional Human Dosing Studies for EPA Regulatory Purposes Scientific and Ethical Issues (2004) / Chapter Skim
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Appendix B: Pharmacokinetics and Metabolism of Pesticides
Appendix B: Pharmacokinetics and Metabolism of Pesticides
Pages 168-172
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From page 168... ...
The stratum corneum is composed largely of tightly adhering, cornified epithelial cells impregnated with sebum and sweat. The lipophilic sebum normally predominates, so as a general rule, lipid-soluble compounds are absorbed more readily than hydrophilic compounds.
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From page 169... ...
Some of the more important endogenous factors include gastric emptying and intestinal motility; gut flora; acid and enzyme secretory activities; cellular transport systems; blood supply; and mucosal structure and surface area. The small intestine has the greatest surface area and is frequently the optimal absorption site.
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From page 170... ...
The preponderance are found in the liver, though certain cell types in different extrahepatic organs exhibit relatively high levels of specific enzymes. There are often considerable interspecies differences in the presence and activity of enzymes and isozymes in particular tissues (Lin, 1995)
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From page 171... ...
1990. Interspecies and interregional analysis of the comparative histological thickness and laser doppler blood flow measurements at five cutaneous sites in nine species.
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From page 172... ...
1998. Age and gender related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities.
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