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Chemical Communication in a Post-Genomic World (2003) / Chapter Skim
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9 Chemical communication among bacteria
Pages 37-42

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From page 37...
... AIPs specifically interact with the external domains of membrane-bound two-component sensor kinase proteins. Interaction of the autoinducer with its cognate sensor stimulates the kinase activity of the sensor kinase protein, resulting in the phosphorylation of its partner response regulator protein.
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From page 38...
... The specificity of the AHL-LuxR pair does not extend to DNA binding and transcriptional activation, because the LuxR proteins all bind to similar DNA regulatory elements termed "lux boxes" (28, 29~. Although interchangeability between AHLs and their LuxR partners is not tolerated, together the pairs can control gene expression at noncognate lux boxes.
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From page 39...
... (A Upper) AHL autoinducers share a common homoserine lactone moiety.
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From page 40...
... cholerae, Clostridium perfringens, and Streptococcus pyogenes; iron acquisition in Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans; antibiotic production in Photorhabdus luminescens; motility in Campylobacter jejuni; and mixed-species biofilm formation between P gingivalis and Streptococcus gordonii (51~.
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From page 41...
... Specificity in autoinducer production and recognition is a key component of quorum sensing, because bacteria must preserve the fidelity of their communication circuits while existing in communities containing other organisms that produce molecules similar to their own autoinducers, either as quorum-sensing autoinducers or as autoinducer antagonists. The use of quorum sensing to control behaviors such as biofilm formation, symbiosis, and virulence factor expression indicates that quorum sensing is frequently used to regulate traits involving interactions between different organisms, both mutualistic and antagonistic.
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From page 42...
... 1. Miller, M
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Key Terms

  • target genes
  • aip signaling
  • lactone ring
  • antibiotic production
  • bacterial species

  • bacillus species
  • target gene
  • homoserine lactone
  • allows bacteria
  • ahl signaling

  • biofilm formation
  • virulence factor
  • chemical communication
  • oxidized halogens
  • particular behaviors

  • luxr proteins
  • cognate response
  • luxi proteins
  • control gene
  • specific dna

  • ahl autoinducers
  • sensor kinase
  • factor expression
  • interspecies communication
  • ralstonia strain

  • hydrolyzes ahls
  • signaling molecules
  • ahl autoinducer
  • chain moiety
  • regulator protein


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