The Development of Science-based Guidelines for Laboratory Animal Care Proceedings of the November 2003 International Workshop (2004) / Chapter Skim
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Appendix D: International Guiding Principles for Biomedical Research Involving Animals (1985)
Appendix D: International Guiding Principles for Biomedical Research Involving Animals (1985)
Pages 240-248
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From page 240... ...
as a result of extensive international and interdisciplinary consultations spanning the three-year period 1982-1984. Animal experimentation is fundamental to the biomedical sciences, not only for the advancement of man's understanding of the nature of life and the mechanisms of specific vital processes, but also for the improvement of methods of prevention, diagnosis, and treatment of disease both in man and in animals.
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From page 241... ...
The Principles strongly emphasize that there should not be such restrictions as would unduly hamper the advance of biomedical science or the performance of necessary biological tests, but that, at the same time, biomedical scientists should not lose sight of their moral obligation to have a humane regard for their animal subjects, to prevent as far as possible pain and discomfort, and to be constantly alert to any possibility of achieving the same result without resort to living animals. The International Guiding Principles are the product of the collaboration of a large and representative sample of the international biomedical community, including experts of the World Health Organization, and of consultations with responsible animal welfare groups.
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From page 242... ...
Interagency Research Animal Committee, were to a considerable extent based on the CIOMS Guiding Principles. In the same year, the Guiding Principles were endorsed by the WHO Advisory Committee on Medical Research at its 26th Session.
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From page 243... ...
There are two international ethical codes intended principally for the guidance of countries or institutions that have not yet formulated their own ethical requirements for human experimentation: the Tokyo revision of the Declaration of Helsinki of the World Medical Association (1975) ; and the Proposed International Guidelines for Biomedical Research Involving Human Subjects of the Council for International Organizations of Medical Sciences and the World Health Organization (1982)
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From page 244... ...
They apply not only to biomedical research but also to all uses of vertebrate animals for other biomedical purposes, including the production and testing of therapeutic, prophylactic, and diagnostic substances, the diagnosis of infections and intoxications in man and animals, and to any other procedures involving the use of intact live vertebrates.
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From page 245... ...
VIII. Where waivers are required in relation to the provisions of article VII, the decisions should not rest solely with the investigators directly concerned but should be made, with due regard to the provisions of articles IV, V, and VI, by a suitably constituted review body.
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From page 246... ...
2.5 Nutrition Animals should receive a supply of foodstuffs appropriate to their requirements and of a quality and quantity adequate to preserve their health, and they should have free access to potable water, unless the object of the experiment is to study the effects of variations of these nutritional requirements. 2.6 Veterinary Care Veterinary care, including a programme of health surveillance and disease prevention, should be available to breeding establishments and to institutions or departments using animals for biomedical purposes.
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From page 247... ...
They may be established by: specific legislation laying down standards and providing for enforcement by an official inspectorate; by more general legislation requiring biomedical research institutions to provide for peer review in accordance with defined principles and criteria, sometimes with informed lay participation; or by voluntary self-regulation by the biomedical community. There are many possible variants of monitoring systems, according to the stress laid upon legislation on the one hand, and voluntary self-regulation on the other.
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From page 248... ...
248 APPENDIX D tive and prospective epidemiological investigations on human and animal populations represent other approaches of major importance. 4.3 The adoption of "alternative" approaches is viewed as being complementary to the use of intact animals and their development and use should be actively encouraged for both scientific and humane reasons.
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