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From page 1...
... 1 EXECUTIVE SUMMARY The 1991 Persian Gulf War was considered a brief and successful military operation with few injuries and deaths. The returning veterans, however, soon began reporting numerous health problems that they believed to be associated with their service in the gulf.
From page 2...
... 2 GULF WAR AND HEALTH scientific evidence and the appropriateness of the scientific methods used to detect the association, (B) the increased risk of the illness among human or animal populations exposed to the agent, hazard, or medicine or vaccine, (C)
From page 3...
... EXECUTIVE SUMMARY 3 Because of the lack of various kinds of data on veterans, the committee could not extrapolate from the exposures in the studies that it reviewed to the exposures of Gulf War veterans. Therefore, it could not determine the likelihood of increased risk of adverse health outcomes among Gulf War veterans due to exposure to the agents examined in this report.
From page 4...
... 4 GULF WAR AND HEALTH members read each study critically and considered its relevance and quality. The committee did not collect original data, nor did it perform any secondary data analysis.
From page 5...
... EXECUTIVE SUMMARY 5 previous IOM committees and have been used to evaluate vaccine safety, herbicides used in Vietnam, and indoor pollutants related to asthma. Sufficient Evidence of a Causal Association Evidence is sufficient to conclude that there is a causal association between exposure to a specific agent and a specific health outcome in humans.
From page 6...
... 6 GULF WAR AND HEALTH Limited/Suggestive Evidence of No Association Evidence is consistent in not showing an association between exposure to a specific agent and a specific health outcome after exposure of any magnitude. A conclusion of no association is inevitably limited to the conditions, magnitudes of exposure, and length of observation in the available studies.
From page 7...
... EXECUTIVE SUMMARY 7 propellant components of Scuds and other missiles used, only hydrazines were found to have a suggestive association with lung cancer. Finally, it should be repeated that the committee was charged with reviewing the scientific data, not with making recommendations regarding the Department of Veterans Affairs policy; therefore, conclusions are not intended to imply or suggest policy decisions.
From page 8...
... 8 GULF WAR AND HEALTH • Hydrazines and lung cancer Reproductive Effects • Combustion products and o Low birthweight/intrauterine growth retardation and exposure during pregnancy o Preterm birth and exposure during pregnancy Respiratory Effects • Combustion products and incident asthma Inadequate/Insufficient Evidence Evidence is of insufficient quantity, quality, or consistency to permit a conclusion regarding the existence of an association between exposure to a specific agent and a specific health outcome in humans. Cancers • Fuels and o Cancers of the oral cavity and oropharynx o Cancers of the nasal cavity and nasopharynx o Esophageal cancer o Stomach cancer o Colon cancer o Rectal cancer o Hepatic cancer o Pancreatic cancer o Laryngeal cancer o Lung cancer o Melanoma o Nonmelanoma skin cancer o Female breast cancer o Male breast cancer o Female genital cancers (cervical, endometrial, uterine, and ovarian cancers)
From page 9...
... EXECUTIVE SUMMARY 9 o Rectal cancer o Hepatic cancer o Pancreatic cancer o Melanoma o Female breast cancer o Male breast cancer o Female genital cancers (cervical, endometrial, uterine, and ovarian cancers) o Prostatic cancer o Testicular cancer o Nervous system cancers o Ocular melanoma o Kidney cancer o Non-Hodgkin’s lymphoma o Hodgkin’s disease o Multiple myeloma o Leukemia o Myelodysplastic syndromes • Hydrazines and o Hematopoietic and lymphopoietic cancers o Digestive tract cancers o Pancreatic cancer o Bladder cancer o Kidney cancer • Nitric acid and: o Stomach cancer o Melanoma o Lymphopoietic cancers o Pancreatic cancer o Laryngeal cancer o Lung cancer o Bladder cancer o Multiple myeloma Reproductive Effects • Fuels and adverse reproductive or developmental outcomes (including infertility, spontaneous abortion, childhood leukemia, CNS tumors, neuroblastoma, and Prader-Willi syndrome)
From page 10...
... 10 GULF WAR AND HEALTH o All childhood cancers identified, including acute lymphocytic leukemia, leukemia, neuroblastoma, and brain cancer Neurologic Effects • Fuels and o Peripheral neuropathy o Neurobehavioral effects o Multiple Chemical Sensitivity symptoms • Combustion products and o Neurobehavioral effects o Posttraumatic stress disorder o Nervous system subgroupings (or individual nervous system diseases) o Multiple Chemical Sensitivity symptoms Respiratory Effects • Fuels and o Nonmalignant respiratory disease o Chronic bronchitis o Asthma o Emphysema • Combustion products and: o Chronic bronchitis (less than 1 year of exposure)
From page 11...
... EXECUTIVE SUMMARY 11 Limited/Suggestive Evidence of No Association Evidence is consistent in not showing a positive association between exposure to a specific agent and a specific health outcome after exposure of any magnitude. A conclusion of no association is inevitably limited to the conditions, magnitudes of exposure, and length of observation in the available studies.

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